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N8410

Sigma-Aldrich

β-Nicotinamide adenine dinucleotide

pkg of 20 mg (per vial)

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Synonym(s):
β-DPN, β-NAD, Coenzyme 1, Cozymase, DPN, Diphosphopyridine nucleotide, Nadide
Empirical Formula (Hill Notation):
C21H27N7O14P2
CAS Number:
53-84-9
Molecular Weight:
663.43
Beilstein:
3584133
EC Number:
200-184-4
MDL number:
MFCD00036253
eCl@ss:
39200202
PubChem Substance ID:
329818687
NACRES:
NA.51

form

powder

Quality Level

200

packaging

pkg of 20 mg (per vial)

storage temp.

−20°C

SMILES string

NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O

InChI

1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

InChI key

BAWFJGJZGIEFAR-NNYOXOHSSA-N

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Application

β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).
β-Nicotinamide adenine dinucleotide has been used in the master mix for coupled enzyme assay to estimate pectin methylesterase activity.

Biochem/physiol Actions

β-Nicotinamide adenine dinucleotide (β-NADH) reduced form is an essential cofactor in all the living organisms. β-NADH functions as a hydride acceptors in biochemical redox reactions. It acts as a cell signaling molecule and is a potent neurotransmitter and neuromodulator in the peripheral nervous system. In brain, it mediates Ca2+ homeostasis, energy metabolism, aging and neuronal death.
Electron acceptor

Other Notes

Packaged based on NAD content as determined by UV-Vis.
This is the common form of NAD.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Release, neuronal effects and removal of extracellular beta-nicotinamide adenine dinucleotide beta-NAD+ in the rat brain
Durnin L, et al.
The European Journal of Neuroscience, 35(3), 423-435 (2012)
Pectin de-methylesterification and AGP increase promote cell wall remodeling and are required during somatic embryogenesis of Quercus suber
Perez-Perez Y, et al.
Frontiers in Plant Science, 9, e894-e894 (2018)
Irina Lazarova et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 83, 70-78 (2016-10-25)
The aim of this study was to investigate the effect of Asphodeline lutea (L.) Rchb. dry root extract (ALE) administered alone and against carbon tetrachloride (CCl4)-induced liver injury in vitro/in vivo. The dried roots of A. lutea were extracted with
Pectin Methylesterase Activity Assay for Plant Material
Mueller K, et al.
Plant Physiology, 3(17), e894-e894 (2013)
The biosynthesis of nicotinamide adenine dinucleotides in bacteria
Begley TP, et al.
Vitamins and Hormones, 61, 103-119 (2001)
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