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Merck
CN

N9289

Sigma-Aldrich

NVP-231

≥98% (HPLC)

Synonym(s):

N-[2-(benzoylamino)-6-benzothiazolyl]-Tricyclo[3.3.1.13,7]decane-1-carboxamide, adamantane-1-carboxylic acid (2-benzoylamino-benzothiazol-6-yl)amide

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About This Item

Empirical Formula (Hill Notation):
C25H25N3O2S
CAS Number:
362003-83-6
Molecular Weight:
431.55
MDL number:
MFCD01988824
UNSPSC Code:
12352200
PubChem Substance ID:
329818618
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >10 mg/mL

originator

Novartis

storage temp.

2-8°C

SMILES string

O=C(Nc1nc2ccc(NC(=O)C34C[C@H]5C[C@H](C[C@H](C5)C3)C4)cc2s1)c6ccccc6

InChI

1S/C25H25N3O2S/c29-22(18-4-2-1-3-5-18)28-24-27-20-7-6-19(11-21(20)31-24)26-23(30)25-12-15-8-16(13-25)10-17(9-15)14-25/h1-7,11,15-17H,8-10,12-14H2,(H,26,30)(H,27,28,29)/t15-,16+,17-,25-

InChI key

MVSSJPGNLQPWSW-CIRRPZLZSA-N

Related Categories

Biochem/physiol Actions

Ceramide kinase presents an attractive target for drug development because of its involvement in cell growth and inflammation.
Ceramide kinase presents an attractive target for drug development because of its involvement in cell growth and inflammation. CerK biology is still poorly understood thus discovery and availability of inhibitors will facilitate research at this area. NVP-231 is a newly discovered potent, specific and reversible CerK inhibitor that competitively inhibits binding of ceraminde to CerK.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000384553
0000384557
0000384553
0000384557
0000198999

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Chee Wai Ku et al.
International journal of molecular sciences, 23(24) (2022-12-24)
The retrograde flow of endometrial tissues deposited into the peritoneal cavity occurs in women during menstruation. Classically (M1) or alternatively (M2) activated macrophages partake in the removal of regurgitated menstrual tissue. The failure of macrophage egress from the peritoneal cavity
Stephanie Schwalm et al.
International journal of molecular sciences, 21(4) (2020-02-26)
Ceramide kinase (CerK) is a lipid kinase that converts the proapoptotic ceramide to ceramide 1-phosphate, which has been proposed to have pro-malignant properties and regulate cell responses such as proliferation, migration, and inflammation. We used the parental human breast cancer
Satoshi Tomizawa et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(6), 158675-158675 (2020-03-01)
Ceramide kinase (CerK) phosphorylates ceramide to ceramide-1-phosphate (C1P), a bioactive sphingolipid. Since the mechanisms responsible for regulating the proliferation and migration/metastasis of cancer cells by the CerK/C1P pathway remain unclear, we conducted the present study. The knockdown of CerK in

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