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Merck
CN

O1266

OPC 31260 hydrochloride

≥98% (HPLC)

Synonym(s):

5-(Dimethylamino)-1-[4-(2-methylbenzamido)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride, Mozavaptan hydrochloride, N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C27H29N3O2 · HCl
CAS Number:
138470-70-9
Molecular Weight:
464.00
NACRES:
NA.77
PubChem Substance ID:
329818895
UNSPSC Code:
51111800
MDL number:
MFCD11111965

Key Documents

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InChI key

MOROBKPIULFQDC-UHFFFAOYSA-N

SMILES string

Cl.CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c4ccccc14

InChI

1S/C27H29N3O2.ClH/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30;/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31);1H

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥15 mg/mL

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

OPC 31260 is a vasopressin V2 selective antagonist. Arginine vasopressin (AVP) plays an important part in circulatory and water homeostasis. The V2 receptor subtype is important in water retention, cardiac remodeling in congestive heart failure (CHF), and renal hemodynamic alterations, and is considered a target for polysystic kidney disease. OPC-31260 has been shown to inhibit the development of polycystic kidney disease in several animal models.
Vasopressin V2 selective antagonist.

Disclaimer

air-sensitive, hygroscopic, store with desiccant

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000159819
031M4730V
0000204714
0000121378

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Li-Hua Xu et al.
The Journal of pharmacology and experimental therapeutics, 373(2), 248-260 (2020-03-14)
It has been identified that arginine vasopressin (AVP), vasopressin receptor 2(V2R), and the aquaporin 2 (AQP2) signaling pathway in the inner ear play important roles in hearing and balance functions through regulating the endolymph equilibrium; however, the contributions of this

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