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O5250

Sigma-Aldrich

D-Ornithine monohydrochloride

~98%

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Synonym(s):
(R)-2,5-Diaminopentanoic acid monohydrochloride
Empirical Formula (Hill Notation):
C5H12N2O2 · HCl
CAS Number:
16682-12-5
Molecular Weight:
168.62
Beilstein:
4153339
EC Number:
240-729-3
MDL number:
MFCD00012917
PubChem Substance ID:
24898012

Assay

~98%

Quality Level

100

form

powder

color

white

mp

239 °C

SMILES string

Cl[H].NCCC[C@@H](N)C(O)=O

InChI

1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m1./s1

InChI key

GGTYBZJRPHEQDG-PGMHMLKASA-N

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Related Categories

Biochem/physiol Actions

D-Ornithine cleave proteins at cysteine residues.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Susan E Cellitti et al.
Nature chemical biology, 7(8), 528-530 (2011-04-29)
D-ornithine has previously been suggested to enhance the expression of pyrrolysine-containing proteins. We unexpectedly discovered that uptake of D-ornithine results in the insertion of a new amino acid, pyrroline-carboxy-lysine (Pcl) instead of the anticipated pyrrolysine (Pyl). Our feeding and biochemical
Nicole Berthold et al.
Antimicrobial agents and chemotherapy, 57(1), 402-409 (2012-11-02)
Proline-rich antimicrobial peptides (PrAMPs) from insects and mammals have recently been evaluated for their pharmaceutical potential in treating systemic bacterial infections. Besides the native peptides, several shortened, modified, or even artificial sequences were highly effective in different murine infection models.
Sherry Dadsetan et al.
Biochemical pharmacology, 85(1), 115-123 (2012-10-30)
Combined administration of ornithine and phenylacetate (OP) is proposed as a novel treatment of hyperammonemia and hepatic encephalopathy. Ornithine is believed to increase ammonia fixation into glutamine in muscle tissue and glutamine is subsequently thought to react with phenylacetate forming
Isabel Araque et al.
Food microbiology, 33(1), 107-113 (2012-11-06)
The accumulation of citrulline and ornithine in wine or beer as a result of the arginine catabolism of some lactic acid bacteria (LAB) species increases the risk of ethyl carbamate and putrescine formation, respectively. Several LAB species, which are found
Irene Tsiapa et al.
Nuclear medicine and biology, 40(2), 262-272 (2012-12-15)
Radiolabeled RGD peptides that specifically target integrin α(ν)β(3) have great potential in early tumor detection through noninvasive monitoring of tumor angiogenesis. Based on previous findings of our group on radiopeptides containing positively charged aminoacids, we developed a new cyclic cRGDfK
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