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Merck
CN

O6012

Orexin A human, rat, mouse

≥97% (HPLC)

Synonym(s):

Hypocretin 1

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About This Item

Empirical Formula (Hill Notation):
C152H243N47O44S4
CAS Number:
205599-75-3
Molecular Weight:
3561.10
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD01635374
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥97% (HPLC)

Key Documents

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Product Name

Orexin A human, rat, mouse, ≥97% (HPLC)

SMILES string

S1SC[C@H](NC(=O)[C@@H](NC(=O)[C@H]5NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC5)NC(=O)[C@@H](NC(=O)[C@H]6N(CCC6)C(=O)[C@@H](NC(=O)[C@H]7N(CCC7)C(=O)[C@H]8NC(=O)CC8)CC(C)C)CC(=O)O)C1)CCCN\C(=N\[H])\N)CCC(=O)N)CCCCN)[C@

InChI

1S/C152H243N47O44S4/c1-20-76(14)118(146(239)188-96(51-74(10)11)138(231)197-119(80(18)201)147(240)180-92(121(156)214)47-70(2)3)195-115(209)62-166-123(216)78(16)171-124(217)79(17)172-131(224)99(55-84-59-162-69-169-84)186-136(229)100(56-111(155)205)174-114(208)61-165-122(215)77(15)170-113(207)60-167-125(218)98(54-83-58-161-68-168-83)185-134(227)95(50-73(8)9)183-132(225)93(48-71(4)5)182-129(222)90(38-41-116(210)211)179-135(228)97(53-82-32-34-85(203)35-33-82)184-133(226)94(49-72(6)7)181-127(220)88(29-24-44-164-152(159)160)177-140(233)104-64-244-245-65-105-141(234)176-87(28-23-43-163-151(157)158)126(219)178-89(36-39-110(154)204)128(221)175-86(27-21-22-42-153)130(223)196-120(81(19)202)148(241)194-107(142(235)190-103(63-200)139(232)192-104)67-247-246-66-106(143(236)193-105)191-137(230)101(57-117(212)213)187-144(237)108-30-26-46-199(108)150(243)102(52-75(12)13)189-145(238)109-31-25-45-198(109)149(242)91-37-40-112(206)173-91/h32-35,58-59,68-81,86-109,118-120,200-203H,20-31,36-57,60-67,153H2,1-19H3,(H2,154,204)(H2,155,205)(H2,156,214)(H,161,168)(H,162,169)(H,165,215)(H,166,216)(H,167,218)(H,170,207)(H,171,217)(H,172,224)(H,173,206)(H,174,208)(H,175,221)(H,176,234)(H,177,233)(H,178,219)(H,179,228)(H,180,240)(H,181,220)(H,182,222)(H,183,225)(H,184,226)(H,185,227)(H,186,229)(H,187,237)(H,188,239)(H,189,238)(H,190,235)(H,191,230)(H,192,232)(H,193,236)(H,194,241)(H,195,209)(H,196,223)(H,197,231)(H,210,211)(H,212,213)(H4,157,158,163)(H4,159,160,164)/t76-,77-,78-,79-,80+,81+,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,118-,119-,120-/m0/s1

InChI key

OFNHNCAUVYOTPM-IIIOAANCSA-N

biological source

synthetic (organic)

sterility

non-sterile

assay

≥97% (HPLC)

form

powder

solubility

1% acetic acid: 1.00-1.04 mg/mL, clear, colorless
water: 1.00-1.04 mg/mL, clear, colorless

UniProt accession no.

O43612
O55232
O55241

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Gene Information

human ... HCRT(3060)
mouse ... Hcrt(15171)
rat ... Hcrt(25723)

Related Categories

Application

Orexin A has been used to study its effect on serum luteinizing hormone (LH) concentration in lateral ventricle in ovariectomized (OVX) gilts and is used to study the behavioral and metabolic effects of central injections of orexin A on pigeons (Columba livia).
Orexin A human, rat, mouse has been used to study its effect on the functioning of porcine pancreatic islets. It has also been used as an orexin receptor 1 (OX1R) antagonist to study the effect of orexin systems in the effect of etonogestrel on respiratory response to prolonged metabolic acidosis.

Biochem/physiol Actions

Orexins (hypocretins) comprise a family of hypothalamic peptides that are involved in the initiation of sleep and in feeding behavior. Orexin A stimulates food intake through activation of the OX1 receptor. Orexin B activates OX2 receptors. Both OX1 and OX2 receptors are involved in maintaining arousal. OX2 receptors appear to be inhibitory autoreceptors on orexin-containing neurons.
Orexins plays a vital role in several physiological functions including feeding, neuroendocrine regulation and arousal. In addition to this, it is also associated with the pathophysiology of narcolepsy. Orexin A, expressed in locus coeruleus (LC) area, binds to orexin-1 (OX1) receptor and regulates rapid eye movement (REM) sleep by acting on the firing rate of noradrenergic neurons. Orexin A release is regulated by suprachiasmatic nucleus (SCN).
Stimulates food intake through activation of the OX1 receptor; both OX1 and OX2 receptors are involved in maintaining arousal.

General description

Orexin A is characterized with an N-terminal pyroglutamyl residue, two intramolecular disulfide bridges and a C-terminal amidation.
Orexin A, also known as hypocretin 1 (hcrt1), is a 33 amino acid excitatory neuropeptide, localized in a small set of neurons in the perifornical area of the hypothalamus. It is synthesized from the precursor protein prepro-orexin in neurons. Orexin A binds to its G-protein-coupled receptor orexin-1 (OX1) which is also called as hcrt receptors 1 (hcrtr1).

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Lot/Batch Number
0000298806
0000298806
0000270791
0000270791
0000144403

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Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons.
Bourgin P
The Journal of Neuroscience, 20(20), 7760-7765 (2000)
Orexin A modulates endocrine function and viability of porcine pancreatic islets
Sassek M, et al.
Journal of Physiology And Pharmacology, 68, 815-821 (2017)
Tao Li et al.
Journal of neuroinflammation, 17(1), 187-187 (2020-06-17)
Orexins are two neuropeptides (orexin A, OXA; orexin B, OXB) secreted mainly from the lateral hypothalamus, which exert a wide range of physiological effects by activating two types of receptors (orexin receptor 1, OXR1; orexin receptor 2, OXR2). OXA has
Behavioral and metabolic effects of central injections of orexins/hypocretins in pigeons (Columba livia).
da Silva ES
Regulatory Peptides, 147(1-3), 9-18 (2008)
Orexin Neurons Contribute to Central Modulation of Respiratory Drive by Progestins on ex vivo Newborn Rodent Preparations
Loiseau C, et al.
Frontiers in Physiology, 10, 159-184 (2019)
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