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O6262

Orexin B rat, mouse

≥97% (HPLC)

Synonym(s):

Hypocretin 2

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About This Item

Empirical Formula (Hill Notation):
C126H215N45O34S
CAS Number:
205599-76-4
Molecular Weight:
2936.40
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD01635376
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥97% (HPLC)
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biological source

synthetic (organic)

Quality Segment

200

sterility

non-sterile

assay

≥97% (HPLC)

form

powder

solubility

1% acetic acid: 1.00-1.04 mg/mL, clear, colorless, water: 1.00-1.04 mg/mL, clear, colorless

UniProt accession no.

O55232, O55241

shipped in

ambient

storage temp.

−20°C

SMILES string

S(CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(

InChI

1S/C126H215N45O34S/c1-18-65(12)99(120(202)166-82(49-64(10)11)117(199)168-100(69(16)172)121(203)156-72(101(133)183)37-44-206-17)167-97(181)57-144-102(184)66(13)150-103(185)67(14)152-111(193)83(50-70-53-140-59-149-70)165-116(198)85(52-93(132)177)155-95(179)55-146-106(188)84(51-92(131)176)161-104(186)68(15)151-107(189)76(32-35-90(129)174)159-114(196)80(47-62(6)7)164-115(197)81(48-63(8)9)163-109(191)74(27-21-40-143-126(138)139)157-110(192)77(33-36-91(130)175)160-113(195)79(46-61(4)5)162-108(190)73(26-20-39-142-125(136)137)153-94(178)54-145-105(187)75(31-34-89(128)173)158-112(194)78(45-60(2)3)154-96(180)56-147-118(200)87-29-23-43-171(87)123(205)88-30-24-41-169(88)98(182)58-148-119(201)86-28-22-42-170(86)122(204)71(127)25-19-38-141-124(134)135/h53,59-69,71-88,99-100,172H,18-52,54-58,127H2,1-17H3,(H2,128,173)(H2,129,174)(H2,130,175)(H2,131,176)(H2,132,177)(H2,133,183)(H,140,149)(H,144,184)(H,145,187)(H,146,188)(H,147,200)(H,148,201)(H,150,185)(H,151,189)(H,152,193)(H,153,178)(H,154,180)(H,155,179)(H,156,203)(H,157,192)(H,158,194)(H,159,196)(H,160,195)(H,161,186)(H,162,190)(H,163,191)(H,164,197)(H,165,198)(H,166,202)(H,167,181)(H,168,199)(H4,134,135,141)(H4,136,137,142)(H4,138,139,143)/t65-,66-,67-,68-,69+,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,99-,100-/m0/s1

InChI key

RLVZFBVFVIDDPQ-GWQFQBPDSA-N

Gene Information

mouse ... Hcrt(15171)
rat ... Hcrt(25723)

General description

Orexin A, also known as hypocretin 1 (hcrt1), is a 33 amino acid excitatory neuropeptide, localized in a small set of neurons in the perifornical area of the hypothalamus. It is synthesized from the precursor protein prepro-orexin in neurons. Orexin A binds to its G-protein-coupled receptor orexin-1 (OX1), which is also called as hcrt receptors 1 (hcrtr1).

Application

Orexin B rat, mouse has been used to test its effect on social interaction in the stress-resilient mice.

Biochem/physiol Actions

Orexins plays a vital role in several physiological functions including feeding, neuroendocrine regulation and arousal. In addition to this, it is also associated with the pathophysiology of narcolepsy. Orexin A, expressed in locus coeruleus (LC) area, binds to orexin-1 (OX1) receptor and regulates rapid eye movement (REM) sleep by acting on the firing rate of noradrenergic neurons. Orexin A release is regulated by suprachiasmatic nucleus (SCN).
Activates OX2 receptors; both OX1 and OX2 receptors are involved in maintaining arousal; OX2 receptors appear to be inhibitory autoreceptors on orexin-containing neurons.
Orexins (hypocretins) comprise a family of hypothalamic peptides that are involved in the initiation of sleep and in feeding behavior. Orexin A stimulates food intake through activation of the OX1 receptor. Orexin B activates OX2 receptors. Both OX1 and OX2 receptors are involved in maintaining arousal. OX2 receptors appear to be inhibitory autoreceptors on orexin-containing neurons.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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