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Merck
CN

O8014

Org 27569

≥98% (HPLC)

Synonym(s):

5-Chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-ylphenyl)ethyl]amide

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About This Item

Empirical Formula (Hill Notation):
C24H28ClN3O
CAS Number:
868273-06-7
Molecular Weight:
409.95
UNSPSC Code:
12352200
PubChem Substance ID:
329818922
EC Number:
278-169-7
MDL number:
MFCD11045300

Key Documents

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InChI key

AHFZDNYNXFMRFQ-UHFFFAOYSA-N

InChI

1S/C24H28ClN3O/c1-2-20-21-16-18(25)8-11-22(21)27-23(20)24(29)26-13-12-17-6-9-19(10-7-17)28-14-4-3-5-15-28/h6-11,16,27H,2-5,12-15H2,1H3,(H,26,29)

SMILES string

CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc3ccc(cc3)N4CCCCC4

assay

≥98% (HPLC)

form

powder

color

white

solubility

H2O: <2 mg/mL, DMSO: >5 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

Org 27569 is an allosteric modulator of CB1 cannabinoid receptor.
Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptor agonist [3H]-CP 55,940 (pKB = 5.67) and causes a significant decrease in specific binding of CB1 receptor inverse agonist SR141716A (Rimonabant; pKB = 5.95); in the reporter gene assay behaves as insurmountable CP 55,940 antagonist; pKB = 7.57 at CB1 receptors in mouse vas deferens

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
051M4615V
077K46161
077K4616

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