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Merck
CN

O9265

Osthole

Synonym(s):

7-Methoxy-8-(3-methyl-2-butenyl)coumarin, 7-Methoxy-8-isopentenylcoumarin, Osthol

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About This Item

Empirical Formula (Hill Notation):
C15H16O3
CAS Number:
Molecular Weight:
244.29
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352205
MDL number:
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assay

≥95% (HPLC)

Quality Segment

form

powder

color

white

solubility

methanol: soluble 10 mg/mL, clear, colorless

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

room temp

SMILES string

COc1ccc2C=CC(=O)Oc2c1C\C=C(\C)C

InChI

1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3

InChI key

MBRLOUHOWLUMFF-UHFFFAOYSA-N

Biochem/physiol Actions

Active constituent of Cnidium monnieri, a traditional Chinese medicine used for its anti-inflammatory, analgesic, and anti-lipedemic activities. Dramatically decreased lipid accumulation in a quail model. Its neuroprotective effect on MPP(+)-induced cytotoxicity in PC12 cells supports the use of osthole as a therapeutic agent for the treatment of neurodegenerative disorders. Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy.


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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