O9764
Anti-OTUB1 (57-70) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-HSPC263, Anti-OTB1, Anti-OTU1, Anti-Otubain 1
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~31 kDa
species reactivity
human
technique(s)
western blot: 1:500-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... OTUB1(55611)
General description
OTUB1 (OTU domain-containing ubiquitin aldehyde binding protein 1), a deubiquitinating enzyme (DUB) is a member of the ovarian tumor (OTU) domain protease superfamily. It is expressed in kidney, intestine, brain, liver and lung. This gene is located on human chromosome 11q13.1.
Immunogen
synthetic peptide corresponding to amino acids 57-70 of human OTUB1
Application
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Biochem/physiol Actions
OTUB1 (OTU domain-containing ubiquitin aldehyde binding protein 1) expression helps to predict the prognosis of hepatocellular carcinoma (HCC) in patients. It can control the T-cell anergy by improving the degradation of the E3 ligase gene related to anergy in lymphocytes (GRAIL).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Regulatory Information
低风险生物材料
常规特殊物品
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Expression of OTUB1 in hepatocellular carcinoma and its effects on HCC cell migration and invasion
Ni Q, et al.
Acta biochimica et biophysica Sinica, 49(8) (2017)
Colon cancer bears overexpression of OTUB1
Liu X, et al.
Pathology Research and Practice, 210(11) (2014)
Qiong Wu et al.
The Journal of biological chemistry, 296, 100466-100466 (2021-03-01)
DNA mismatch repair (MMR) maintains genome stability primarily by correcting replication errors. MMR deficiency can lead to cancer development and bolsters cancer cell resistance to chemotherapy. However, recent studies have shown that checkpoint blockade therapy is effective in MMR-deficient cancers
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination
Baietti MF, et al.
EMBO Molecular Medicine, 8(3) (2016)
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