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O9765

Orientin

≥97% (HPLC)

Synonym(s):

8-β-D-Glucopyranosyl-3′,4′,5,7-tetrahydroxyflavone, Luteolin 8-C-β-D-glucopyranoside, Luteolin-8-glucoside, Lutexin

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About This Item

Empirical Formula (Hill Notation):
C21H20O11
CAS Number:
28608-75-5
Molecular Weight:
448.38
NACRES:
NA.25
PubChem Substance ID:
329818945
UNSPSC Code:
12352205
MDL number:
MFCD00017432
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Quality Level

100

assay

≥97% (HPLC)

form

powder

color

yellow

solubility

1 M NaOH: 1 mg/mL, clear, yellow-orange

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)cc(O)c3C(=O)C=C(Oc23)c4ccc(O)c(O)c4

InChI

1S/C21H20O11/c22-6-14-17(28)18(29)19(30)21(32-14)16-11(26)4-10(25)15-12(27)5-13(31-20(15)16)7-1-2-8(23)9(24)3-7/h1-5,14,17-19,21-26,28-30H,6H2/t14-,17-,18+,19-,21+/m1/s1

InChI key

PLAPMLGJVGLZOV-VPRICQMDSA-N

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General description

Orientin (ORI) is a luteolin derivative and water soluble 8-C-glucoside dietary flavone. It has one ketone, two ether, and phenyl groups in its chemical structure. Orientin is sourced from many medicinal plants such as Ocimum sanctum (holy basil), Phyllostachys species (bamboo leaves), Passiflora species, Trollius species, etc.

Application

Orientin has been used:
  • as an anti-inflammatory and anti-proliferative agent to test its protective effects against 1,2-dimethyl hydrazine (DMH)-induced colorectal cancer in rats model
  • as a flavanoid to investigate its protective effects against mitochondrial dysfunction on antimycin-A induced murine C2C12 skeletal muscle cells
  • as a potential endonuclease inhibitor of influenza polymerase PA subunit

Biochem/physiol Actions

Flavonoid glycoside found in the acai tree and globe and passion flowers. Antiviral, antimicrobial and antioxidant. Exhibits radioprotective activities.
Orientin displays neuroprotective effects against hydrogen peroxide-induced SH-SY5Y neuroblastoma cells. It exerts antioxidant, anti-inflammation, antiaging, antidepressant-like, vasodilation, vasorelaxant, and cardioprotective effects.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ9522
MKCV4916
MKCT8309
MKCN7655
MKCL8434

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A Rovirosa et al.
Acta neurologica Belgica, 92(1), 30-35 (1992-01-01)
Meningeal Fibrosarcoma (MF) accounts only for 0.5% of the brain tumors. Since the clinical manifestations and radiologic findings are non-specific, the diagnosis can only be achieved by pathological examination of surgically removed specimens. MF are tumors that behave locally very
Sinenhlanhla X H Mthembu et al.
Molecules (Basel, Switzerland), 26(20) (2021-10-24)
The current study investigated the physiological effects of flavonoids found in daily consumed rooibos tea, aspalathin, isoorientin, and orientin on improving processes involved in mitochondrial function in C2C12 myotubes. To achieve this, C2C12 myotubes were exposed to a mitochondrial channel
Benjamin Ngee Tiing Law et al.
Molecular medicine reports, 9(3), 947-954 (2013-12-25)
Neurodegenerative diseases remain a global issue which affects the ageing population. Efforts towards determining their aetiologies to understand their pathogenic mechanisms are underway in order to identify a pathway through which therapeutic measures can be applied. One such pathogenic mechanism
H Costa et al.
Acta orthopaedica Belgica, 58(1), 3-10 (1992-01-01)
The authors studied the results of a homogeneous group of 60 knees on which were performed intra- and extraarticular ligamentoplasty for chronic anterior laxity. The MacIntosh technique as described by Imbert was used. This consisted of a continuous transplant taken
Detection of atrial tachyarrhythmias by transesophageal pacing and recording at rest and during exercise in children with ventricular preexcitation.
F Drago et al.
The American journal of cardiology, 69(12), 1098-1099 (1992-04-25)
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Global Trade Item Number

SKUGTIN
O9765-5MG04061834248958
O9765-1MG04061834248941

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