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P0021

Pantoprazole sodium hydrate

≥98% (HPLC), gastric proton pump inhibitor, powder

Synonym(s):

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate, Pantozol hydrate, Protonix hydrate

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About This Item

Empirical Formula (Hill Notation):
C16H14F2N3O4S · Na · xH2O
CAS Number:
718635-09-7
Molecular Weight:
405.35 (anhydrous basis)
UNSPSC Code:
12352203
PubChem Substance ID:
329819976
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated
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Product Name

Pantoprazole sodium hydrate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

white to off-white

solubility

H2O: ≥20 mg/mL

originator

Novartis

storage temp.

−20°C

SMILES string

O.[Na+].COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[n-]2)c1OC

InChI

1S/C16H14F2N3O4S.Na.H2O/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;;/h3-7,15H,8H2,1-2H3;;1H2/q-1;+1;

InChI key

CGJRLPRCWSHOFU-UHFFFAOYSA-N

Gene Information

human ... ATP4A(495), ATP4B(496)

Application

Pantoprazole sodium hydrate has been used:
  • as a standard in high-performance liquid chromatography (HPLC){58
  • as a prazole to study its effects on prodrug activation and human immunodeficiency virus 1 (HIV-1) inhibition
  • to study its effects on breast cancer resistance protein (BCRP) inhibitors in various in vitro membrane preparations from various cell lines

Biochem/physiol Actions

Pantoprazole is a benzimidazole derivative,activated in acidic environment. It is useful in treating long term prophylaxis and acid-related disorders.
Pantoprazole has the potential to treat symptoms of heartburn and acid regurgitation. It also has been studied to treat Helicobacter pylori infection and duodenal ulcer.
Pantoprazole is a gastric proton pump inhibitor.

Features and Benefits

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000322842
0000322842
0000322841
0000322841
0000237244

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A Fitton et al.
Drugs, 51(3), 460-482 (1996-03-01)
Pantoprazole is an irreversible proton pump inhibitor which, at the therapeutic dose of 40mg, effectively reduces gastric acid secretion. In controlled clinical trials, pantoprazole (40mg once daily) has proved superior to ranitidine (300mg once daily or 150mg twice daily) and
Analysis of ibuprofen, pantoprazole, and itopride combination therapeutic drugs in human plasma by solid phase membrane microtip extraction and high-performance liquid chromatography methods using new generation core shell C18 column
Ali I, et al.
Journal of Liquid Chromatography and Related Technologies, 39(7), 339-345 (2016)
Pantoprazole
<BIG>Perry CM and Ibbotson T</BIG>
Drugs, 101-132 (2003)
View All Related Papers

Global Trade Item Number

SKUGTIN
P0021-50MG04061833219935
P0021-10MG04061834261865