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P0021

Pantoprazole sodium hydrate

Name: Pantoprazole sodium hydrate
Brand: SIGMA

≥98% (HPLC), gastric proton pump inhibitor, powder

Synonym(s):

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate, Pantozol hydrate, Protonix hydrate

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₄F₂N₃O₄S · Na · xH₂O

CAS Number:

718635-09-7

Molecular Weight:

405.35 (anhydrous basis)

UNSPSC Code:

12352203

PubChem Substance ID:

329819976

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

Pantoprazole sodium hydrate, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

white to off-white

solubility

H₂O: ≥20 mg/mL

originator

Novartis

storage temp.

−20°C

SMILES string

O.[Na+].COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[n-]2)c1OC

InChI

1S/C16H14F2N3O4S.Na.H2O/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;;/h3-7,15H,8H2,1-2H3;;1H2/q-1;+1;

InChI key

CGJRLPRCWSHOFU-UHFFFAOYSA-N

Gene Information

human ... ATP4A(495), ATP4B(496)

Description

Application

Pantoprazole sodium hydrate has been used:

as a standard in high-performance liquid chromatography (HPLC){58
as a prazole to study its effects on prodrug activation and human immunodeficiency virus 1 (HIV-1) inhibition
to study its effects on breast cancer resistance protein (BCRP) inhibitors in various in vitro membrane preparations from various cell lines

Biochem/physiol Actions

Pantoprazole is a benzimidazole derivative,activated in acidic environment. It is useful in treating long term prophylaxis and acid-related disorders.

Pantoprazole has the potential to treat symptoms of heartburn and acid regurgitation. It also has been studied to treat Helicobacter pylori infection and duodenal ulcer.

Pantoprazole is a gastric proton pump inhibitor.

Features and Benefits

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c