P0022
PS48
≥98% (HPLC)
Synonym(s):
5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid
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About This Item
Empirical Formula (Hill Notation):
C17H15ClO2
CAS Number:
Molecular Weight:
286.75
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
LLJYFDRQFPQGNY-QINSGFPZSA-N
SMILES string
OC(=O)\C=C(\CCc1ccc(Cl)cc1)c2ccccc2
InChI
1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to off-white
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site.
PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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