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Merck
CN

P0081

Monoclonal Anti-PMP22 antibody produced in mouse

~1.0 mg/mL, clone CF1, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-CMT1A, Anti-Charcot-Marie-Tooth neuropathy 1A, Anti-GAS3, Anti-Growth arrest-specific 3, Anti-HNPP, Anti-Peripheral myelin protein 22

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About This Item

UNSPSC Code:
12352203

Key Documents

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Product Name

Monoclonal Anti-PMP22 antibody produced in mouse, ~1.0 mg/mL, clone CF1, purified immunoglobulin, buffered aqueous solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

CF1, monoclonal

form

buffered aqueous solution

mol wt

antigen ~22 kDa

species reactivity

human, monkey

packaging

antibody small pack of 25 μL

concentration

~1.0 mg/mL

technique(s)

immunocytochemistry: suitable
immunohistochemistry: 2.5-5 μg/mL using human spinal cord tissue sections.
indirect ELISA: suitable
western blot: suitable

isotype

IgG1

UniProt accession no.

Q01453

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PMP22(5376)

Biochem/physiol Actions

Peripheral myelin protein 22 (PMP22) plays a vital role in myelination during peripheral nerve development. It also has a role in cell-cell interactions, cell proliferation, maintenance of axons and the determination of myelin thickness and stability. Aberrations or mutations in the PMP22 gene lead to heritable demyelinating peripheral neuropathies, such as Charcot-Marie-tooth disease type IA (CMT1A) and Dejerine-Sottas syndrome. Overexpression of PMP22 might contribute to the development of chronic myeloid leukemia (CML).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Peripheral myelin protein 22 (PMP22), also known as growth arrest-specific protein 3 (GAS-3), is a tetraspan glycoprotein. It is highly expressed in myelin-forming Schwann cells of peripheral nerves. The gene encoding it is localized on human chromosome 17p12–13.

Immunogen

peptide corresponding to the second extracellular domain of human PMP22 (amino acids 120-133).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
014M4777V
068K4792
068K4793

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Isolation and mapping to 17p12-13 of the human homologous of the murine growth arrest specific Gas-3 gene.
Martinotti A
Human Molecular Genetics (1992)
Knockdown of Peripheral Myelin Protein 22 Inhibits the Progression of Chronic Myeloid Leukemia.
Liu H
Oncology Research (2014)
Many facets of the peripheral myelin protein PMP22 in myelination and disease.
Microscopy Research and Technique (1998)
Peripheral myelin protein 22 is a constituent of intercellular junctions in epithelia.
Notterpek L
Proceedings of the National Academy of Sciences of the USA (2001)
Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice.
Adlkofer K
Nature Genetics (1995)
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Related Content

Data Sheet - P0081

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