P0108
PRL-3 Inhibitor I
≥98% (HPLC), solid
Synonym(s):
5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone, Phosphatase of regenerating liver-3, Inhibitor I
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About This Item
Empirical Formula (Hill Notation):
C17H11Br2NO2S2
CAS Number:
Molecular Weight:
485.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
protect from light
Quality Segment
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
yellow
solubility
DMSO: >10 mg/mL, H2O: <2 mg/mL
storage temp.
−20°C
SMILES string
Brc1ccc(OCc2ccccc2Br)c(c1)\C=C3\SC(=S)NC3=O
InChI
1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)/b15-8+
InChI key
HXNBAOLVPAWYLT-OVCLIPMQSA-N
Application
PRL-3 Inhibitor I has been used as an inhibitor of phosphatase of regenerating liver-3 (PRL-3):
- to test its effect on classical Hodgkin lymphoma cell survival
- in the human umbilical vein endothelial cells tube formation assay
- to test its effect on the migration of neural crest cells
Biochem/physiol Actions
PRL-3 Inhibitor I is a rhodanine derivative with an IC50 value of 0.9 μM against phosphatase of regenerating liver-3 (PRL-3), a nonclassical protein tyrosine phosphatase that has recently been shown to be involved in cancer metastasis. PRL-3 Inhibitor I reduced the invasiveness of B16F10 melanoma cells in a cell based assay.
Features and Benefits
This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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