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P0618

cis-8-Hydroxy-3-(n-propyl)-1,2,3a,4,5,9b-hexahydro-1H-benz[e]indole hydrobromide

≥98% (HPLC), solid

Synonym(s):

cis(±)-8-OH-PBZI hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C15H21NO · HBr
Molecular Weight:
312.25
NACRES:
NA.77
PubChem Substance ID:
24278794
UNSPSC Code:
12352202
MDL number:
MFCD11045999
Assay:
≥98% (HPLC)
Form:
solid
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assay

≥98% (HPLC)

form

solid

color

light brown

solubility

H2O: soluble ~10 mg/mL at 60 °C (Sonicate), DMSO: soluble 12 mg/mL

storage temp.

2-8°C

SMILES string

Br.CCCN1CC[C@@H]2[C@H]1CCc3ccc(O)cc23

InChI

1S/C15H21NO.BrH/c1-2-8-16-9-7-13-14-10-12(17)5-3-11(14)4-6-15(13)16;/h3,5,10,13,15,17H,2,4,6-9H2,1H3;1H/t13-,15+;/m0./s1

InChI key

UMGQLEXNQCHIFN-NQQJLSKUSA-N

Gene Information

human ... DRD3(1814)

Biochem/physiol Actions

D3 dopamine receptor agonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
112K4612

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E V Kuzhikandathil et al.
Pharmaceutical research, 29(8), 2264-2275 (2012-05-02)
The D3 dopamine receptor exhibits tolerance and slow response termination (SRT) properties that are not exhibited by the closely-related D2 dopamine receptor. We previously demonstrated that the induction of tolerance elicits a unique conformational change in the D3 receptor. Here
Ligia Westrich et al.
Biochemical pharmacology, 79(6), 897-907 (2009-11-03)
The D3 but not D2 dopamine receptors exhibit a tolerance property in which agonist-induced D3 receptor response progressively decreases upon repeated agonist stimulation. We have previously shown that the D3 receptor tolerance property is not mediated by receptor internalization, persistent

Global Trade Item Number

SKUGTIN
P0618-25MG04061832083490