P0643
5-Propyl-2-thiouracil
≥98%
Synonym(s):
PTU
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About This Item
Empirical Formula (Hill Notation):
C7H10N2OS
CAS Number:
Molecular Weight:
170.23
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Assay:
≥98%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow
InChI key
RWJRFPUNLXBCML-UHFFFAOYSA-N
SMILES string
CCCC1=CNC(=S)NC1=O
InChI
1S/C7H10N2OS/c1-2-3-5-4-8-7(11)9-6(5)10/h4H,2-3H2,1H3,(H2,8,9,10,11)
biological source
synthetic (organic)
assay
≥98%
form
powder
solubility
1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow
Quality Level
Application
5-Propyl-2-thiouracil (PTU) is used to induce and study mechanisms of hypothyroidism at the levels of thyroid hormone biosynthesis and gene regulation.
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Alexander G Little et al.
BMC biology, 11, 26-26 (2013-03-28)
Thyroid hormone (TH) is best known for its role in development in animals, and for its control of metabolic heat production (thermogenesis) during cold acclimation in mammals. It is unknown whether the regulatory role of TH in thermogenesis is derived
Alessandra Gentili et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 33(12), 1793-1802 (2016-10-04)
This paper describes a rapid method for confirming residues of thyreostats in meat-based baby foods by using liquid chromatography - dual polarity electrospray - tandem mass spectrometry (LC-ES(±)-MS/MS). Six thioureylenes, belonging to the group of thiouracil and imidazole, were selected
Marion F Haug et al.
Frontiers in zoology, 7, 8-8 (2010-03-03)
Visual acuity, the ability of the visual system to distinguish two separate objects at a given angular distance, is influenced by the optical and neuronal properties of the visual system. Although many factors may contribute, the ultimate limit is photoreceptor
Dong Hyun Jo et al.
Molecular cancer, 12, 71-71 (2013-07-10)
With high throughput screening, novel therapeutic agents can be efficiently identified. Unfortunately, researchers only resort to in vitro cell viability assays for screening of anticancer drugs for retinoblastoma, the most common intraocular cancer in the childhood. Current available animal models
Ayumi Nagasawa-Masuda et al.
PloS one, 12(4), e0174633-e0174633 (2017-04-04)
Vascular regression is essential to remove redundant vessels during the formation of an efficient vascular network that can transport oxygen and nutrient to every corner of the body. However, no mechanism is known to explain how major blood vessels regress
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