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Safety Information

P0643

Sigma-Aldrich

5-Propyl-2-thiouracil

≥98%

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Synonym(s):
PTU
Empirical Formula (Hill Notation):
C7H10N2OS
CAS Number:
2954-52-1
Molecular Weight:
170.23
MDL number:
MFCD00057340
PubChem Substance ID:
24898118
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

100

Assay

≥98%

form

powder

solubility

1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow

SMILES string

CCCC1=CNC(=S)NC1=O

InChI

1S/C7H10N2OS/c1-2-3-5-4-8-7(11)9-6(5)10/h4H,2-3H2,1H3,(H2,8,9,10,11)

InChI key

RWJRFPUNLXBCML-UHFFFAOYSA-N

Application

5-Propyl-2-thiouracil (PTU) is used to induce and study mechanisms of hypothyroidism at the levels of thyroid hormone biosynthesis and gene regulation.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H351

Precautionary Statements

P281

Hazard Classifications

Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Marion F Haug et al.
Frontiers in zoology, 7, 8-8 (2010-03-03)
Visual acuity, the ability of the visual system to distinguish two separate objects at a given angular distance, is influenced by the optical and neuronal properties of the visual system. Although many factors may contribute, the ultimate limit is photoreceptor
Nadine Bohni et al.
PloS one, 8(5), e64006-e64006 (2013-05-24)
Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovery. Several challenges nevertheless persist with respect to NP discovery, including the time and effort required for bioassay-guided isolation of bioactive NPs, and the limited biomedical relevance
Ayumi Nagasawa-Masuda et al.
PloS one, 12(4), e0174633-e0174633 (2017-04-04)
Vascular regression is essential to remove redundant vessels during the formation of an efficient vascular network that can transport oxygen and nutrient to every corner of the body. However, no mechanism is known to explain how major blood vessels regress
Dong Hyun Jo et al.
Molecular cancer, 12, 71-71 (2013-07-10)
With high throughput screening, novel therapeutic agents can be efficiently identified. Unfortunately, researchers only resort to in vitro cell viability assays for screening of anticancer drugs for retinoblastoma, the most common intraocular cancer in the childhood. Current available animal models
Alessandra Gentili et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 33(12), 1793-1802 (2016-10-04)
This paper describes a rapid method for confirming residues of thyreostats in meat-based baby foods by using liquid chromatography - dual polarity electrospray - tandem mass spectrometry (LC-ES(±)-MS/MS). Six thioureylenes, belonging to the group of thiouracil and imidazole, were selected
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