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P1038

Poly(cytidylic-inosinic) acid potassium salt

random copolymer

Synonym(s):

Poly (C,I)

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About This Item

CAS Number:
26301-44-0
UNSPSC Code:
41106305
NACRES:
NA.51
MDL number:
MFCD00167396
Form:
powder
Storage temp.:
−20°C
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Quality Segment

200

form

powder

storage temp.

−20°C

Application

Poly(cytidylic-inosinic) acid potassium salt has been used:
  • in pretreatment to understand Con A-induced hepatitis in mice
  • in RNA extraction from hemolymph plasma for qPCR detection assay
  • to induce inflammatory changes in liver
  • as a component of minimal essential medium for the stimulation of rainbow trout gonad line RTG-2 cells

Biochem/physiol Actions

Poly(cytidylic-inosinic) acid, poly I:C mimics viral RNA to induce immune response. Administration of poly I:C promotes cytotoxic functionality of natural killer cells and macrophages. However, poly I:C may trigger generation of anti-mitochondrial antibodies (AMAs) and contribute to the pathogenesis of primary biliary cirrhosis (PBC). Poly I:C may play a hepatoprotective role in Con A-induced T cell-dependent liver injury.
Poly(cytidylic-inosinic) Poly(C,I) is a random copolymer of inosine and cytidine bases which may be useful for comparative physicochemical analysis versus other random copolymers such as Poly(C,A), Poly(C,U) and Poly(C,G).

Other Notes

Random copolymer

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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