P1038
Poly(cytidylic-inosinic) acid potassium salt
random copolymer
Synonym(s):
Poly (C,I)
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About This Item
Form:
powder
Storage temp.:
−20°C
Application
Poly(cytidylic-inosinic) acid potassium salt has been used:
- in pretreatment to understand Con A-induced hepatitis in mice
- in RNA extraction from hemolymph plasma for qPCR detection assay
- to induce inflammatory changes in liver
- as a component of minimal essential medium for the stimulation of rainbow trout gonad line RTG-2 cells
Biochem/physiol Actions
Poly(cytidylic-inosinic) acid, poly I:C mimics viral RNA to induce immune response. Administration of poly I:C promotes cytotoxic functionality of natural killer cells and macrophages. However, poly I:C may trigger generation of anti-mitochondrial antibodies (AMAs) and contribute to the pathogenesis of primary biliary cirrhosis (PBC). Poly I:C may play a hepatoprotective role in Con A-induced T cell-dependent liver injury.
Poly(cytidylic-inosinic) Poly(C,I) is a random copolymer of inosine and cytidine bases which may be useful for comparative physicochemical analysis versus other random copolymers such as Poly(C,A), Poly(C,U) and Poly(C,G).
Other Notes
Random copolymer
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| P1038-10MG | 04061834353881 |
| P1038-5MG | 04061834353898 |