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Merck
CN

P1152

Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide

greener alternative

Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000

Synonym(s):

(L-Ala, L-Glu, L-Lys, L-Tyr)n ·HBr, COP-1

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About This Item

CAS Number:
28704-27-0
UNSPSC Code:
12352202
NACRES:
NA.26
MDL number:
MFCD00166401

Key Documents

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Product Name

Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide, Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000

SMILES string

N[C@@H](CCCCN)C(=O)O.N[C@@H](Cc1ccc(cc1)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](C)C(=O)O

InChI

1S/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6)/t8-;5-;3-;2-/m0000/s1

InChI key

YLOCGHYTXIINAI-XKUOMLDTSA-N

form

powder

feed ratio

Ala:Glu:Lys:Tyr (6:2:5:1)

mol wt

20,000-30,000

greener alternative product score

old score: 56
new score: 39
Find out more about DOZN™ Scoring

greener alternative product characteristics

Designing Safer Chemicals
Safer Solvents and Auxiliaries
Reduce Derivatives
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

color

white to off-white

greener alternative category

, Re-engineered

storage temp.

−20°C

Quality Level

200

Related Categories

Analysis Note

Reported molecular weight based on viscosity.

Biochem/physiol Actions

Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide is a polyamino acid reported to have a suppressive effect on allergic encephalomyelitis.
Reported to have suppressive effect on experimental allergic encephalomyelitis induced in laboratory animals.

General description

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Designing Safer Chemicals”, "Safer Solvents and Auxiliaries" and “Reduce Derivatives”. Click here to view its DOZN scorecard.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000331726
0000331726
0000276030
0000276030
SLBH2744V

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Dominant epitopes and synthetic peptides in myasthenia gravis.
M Sela et al.
Israel journal of medical sciences, 31(1), 10-12 (1995-01-01)
Expanded clinical trials of treatments for multiple sclerosis: copolymer 1 (COP-1) treatment investigational new drug (IND) program.
Y Stark
Annals of neurology, 36(1), 114-115 (1994-07-01)
Carmen C M Chan
Recent patents on CNS drug discovery, 3(3), 189-199 (2008-11-11)
Spinal cord injury leads to a devastating cascade of secondary complications that eventually results in the formation of scar tissue many times the size of the original insult. Inflammation plays a very important role towards the development of such scar
E Zisman et al.
European journal of immunology, 24(10), 2497-2505 (1994-10-01)
Studies with the well-characterized, synthetic, random-multichain polypeptide poly(LTyr,LGlu)-poly(DLAla)-poly(LLys) (T,G)-A-L) led to the discovery of determinant-specific genetic control of the immune response, as well as to other immunological phenomena. Moreover, the tetrapeptide TyrTyrGluGlu built on the same backbone ("(T-T-G-G)-A--L") was found
Byoung-Joo Choi et al.
Japanese heart journal, 45(4), 697-702 (2004-09-09)
A 16 year-old Korean girl with cardiomegaly was found to have a "right atrial cystic mass" on transthoracic echocardiography. An unusual cystic structure made the diagnosis difficult. However, transesophageal echocardiography and multidetector computed tomography revealed a coronary artery fistula with
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