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Merck
CN

P1152

Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide

greener alternative

Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000

Synonym(s):

(L-Ala, L-Glu, L-Lys, L-Tyr)n ·HBr, COP-1

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About This Item

CAS Number:
28704-27-0
UNSPSC Code:
12352202
NACRES:
NA.26
MDL number:
MFCD00166401

Key Documents

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SMILES string

N[C@@H](CCCCN)C(=O)O.N[C@@H](Cc1ccc(cc1)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](C)C(=O)O

InChI

1S/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6)/t8-;5-;3-;2-/m0000/s1

InChI key

YLOCGHYTXIINAI-XKUOMLDTSA-N

form

powder

feed ratio

Ala:Glu:Lys:Tyr (6:2:5:1)

mol wt

20,000-30,000

greener alternative product score

old score: 56
new score: 39
Find out more about DOZN™ Scoring

greener alternative product characteristics

Designing Safer Chemicals
Safer Solvents and Auxiliaries
Reduce Derivatives
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

color

white to off-white

greener alternative category

, Re-engineered

storage temp.

−20°C

Quality Level

200

Related Categories

General description

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Designing Safer Chemicals”, "Safer Solvents and Auxiliaries" and “Reduce Derivatives”. Click here to view its DOZN scorecard.

Biochem/physiol Actions

Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide is a polyamino acid reported to have a suppressive effect on allergic encephalomyelitis.
Reported to have suppressive effect on experimental allergic encephalomyelitis induced in laboratory animals.

Analysis Note

Reported molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000331726
0000331726
0000276030
0000276030
SLBH2744V

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M Fridkis-Hareli et al.
Human immunology, 62(8), 753-763 (2001-07-31)
Copolymer 1 (Cop 1, poly [Y, E, A, K]) is a random synthetic amino acid copolymer effective in the treatment of relapsing forms of multiple sclerosis (MS), a disease that is linked to HLA-DR2 (DRB1*1501). In the present study various
L Jacobs et al.
Current opinion in neurology, 7(3), 250-254 (1994-06-01)
During the past year, two new agents have been demonstrated to be of value in multiple sclerosis. The first agent, a form of recombinant interferon beta (Betaseron; Berlex Labs, Cedar Knolls, NJ), is effective in reducing relapses and also prevent
On-line trypsin-encapsulated enzyme reactor by the sol-gel method integrated into capillary electrophoresis
Sakai-Kato, K., Kato, M. and Toyo'oka T.
Analytical Chemistry, 72, 2943-2949 (2002)
The development of Cop 1 (Copaxone), an innovative drug for the treatment of multiple sclerosis: personal reflections.
R Arnon
Immunology letters, 50(1-2), 1-15 (1996-04-01)
Designing rational therapies for multiple sclerosis.
L Steinman et al.
Bio/technology (Nature Publishing Company), 13(2), 118-120 (1995-02-01)
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Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

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