P119
(±)-Pindobind
solid
Synonym(s):
N8-Bromoacetyl-N1-3′-(4-indolyloxy)-2′-hydroxy-propyl-(Z)-1,8-diamino-p-menthane
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About This Item
Empirical Formula (Hill Notation):
C23H34BrN3O3
CAS Number:
Molecular Weight:
480.44
UNSPSC Code:
12352103
MDL number:
form
solid
color
white
solubility
DMSO: soluble, ethanol: soluble, methanol: soluble
storage temp.
−20°C
Biochem/physiol Actions
Analog of pindolol that contains a bromo-acetyl group capable of alkylating β-adrenergic receptors; easily radioiodinated.
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R J Box
Journal of receptor research, 9(4-5), 385-403 (1989-01-01)
The reactivities with beta-adrenergic receptors of the bromoacetyl derivatives of the beta-adrenergic antagonists alprenolol and pindolol, BAAM and BIM, respectively, were compared in intact S49 mouse lymphoma cells. Both compounds caused irreversible blockade of receptors and changes in the mobility
P Molenaar et al.
Biochemical pharmacology, 37(19), 3601-3607 (1988-10-01)
The actions of alkylating pindolol (N8-bromoacetyl-N1-3'-(4-indolyloxy)-2'-hydroxypropyl[z]-1,8- diamino-p-menthane; BIM) have been examined on beta-adrenoceptors in guinea-pig left atria and trachea. In organ bath experiments, addition of BIM (greater than or equal to 0.1 microM), followed by washout, produced concentration-dependent rightward shifts
J Pitha et al.
Journal of medicinal chemistry, 30(4), 612-615 (1987-04-01)
New alkylating ligands derived from indole with high affinity for beta-adrenoceptors were synthesized and their properties examined. N8-(Bromoacetyl)-N1-[3-(4-indolyloxy)-2-hydroxypropyl]-(Z)-1,8-dia mino-p- menthane (8) and its N1,N8 isomer (9) were prepared by the reaction of bromoacetyl bromide with a product of the condensation
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