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P1223

L-α-Phosphatidylethanolamine, dioleoyl

Name: <SC>L</SC>-α-Phosphatidylethanolamine, dioleoyl
Brand: SIGMA

≥99% (GC), ≥98% (TLC), lyophilized powder

Synonym(s):

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, (9Z)-9-Octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester, 1,2-Di(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine, 3-sn-Phosphatidylethanolamine, 1,2-dideoyl, L-β,γ-Dioleoyl-α-cephalin, DOPE, Dioleoyl phosphatidylethanolamine, PE(18:1(9Z)/18:1(9Z))

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About This Item

Empirical Formula (Hill Notation):

C₄₁H₇₈NO₈P

CAS Number:

4004-05-1

Molecular Weight:

744.03

UNSPSC Code:

12352211

NACRES:

NA.25

PubChem Substance ID:

24898174

MDL number:

MFCD00057986

Beilstein/REAXYS Number:

1718431

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biological source

synthetic

Quality Level

200

assay

≥98% (TLC), ≥99% (GC)

form

lyophilized powder

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

SMILES string

CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC

InChI

1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-

InChI key

MWRBNPKJOOWZPW-CLFAGFIQSA-N

Related Categories

Biochemicals

Application

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents .

Forms liposomes with DC-cholesterol that can be used to efficiently transfect several mammalian cell lines.

Packaging

Packaged under Argon.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000487038

0000287906

SLCN8777

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Proteomic Analysis and Functional Characterization of P4-ATPase Phospholipid Flippases from Murine Tissues.

Jiao Wang et al.

Scientific reports, 8(1), 10795-10795 (2018-07-19)

P4-ATPases are a subfamily of P-type ATPases that flip phospholipids across membranes to generate lipid asymmetry, a property vital to many cellular processes. Mutations in several P4-ATPases have been linked to severe neurodegenerative and metabolic disorders. Most P4-ATPases associate with

Hybrid cell reactor system from Escherichia coli protoplast cells and arrayed lipid bilayer chamber device.

Yoshiki Moriizumi et al.

Scientific reports, 8(1), 11757-11757 (2018-08-08)

We developed a novel hybrid cell reactor system via functional fusion of single Escherichia coli protoplast cells, that are deficient in cell wall and expose plasma membrane, with arrayed lipid bilayer chambers on a device in order to incorporate the

Cationic Nanoliposomes Meet mRNA: Efficient Delivery of Modified mRNA Using Hemocompatible and Stable Vectors for Therapeutic Applications.

Tatjana Michel et al.

Molecular therapy. Nucleic acids, 8, 459-468 (2017-09-18)

Synthetically modified mRNA is a unique bioactive agent, ideal for use in therapeutic applications, such as cancer vaccination or treatment of single-gene disorders. In order to facilitate mRNA transfections for future therapeutic applications, there is a need for the delivery

Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes.

Juliette Fedry et al.

PLoS biology, 16(8), e2006357-e2006357 (2018-08-14)

HAPLESS2 (HAP2) is a broadly conserved, gamete-expressed transmembrane protein that was shown recently to be structurally homologous to viral class II fusion proteins, which initiate fusion with host cells via insertion of fusion loops into the host membrane. However, the

Intradermal vaccination with hollow microneedles: A comparative study of various protein antigen and adjuvant encapsulated nanoparticles.

Guangsheng Du et al.

Journal of controlled release : official journal of the Controlled Release Society, 266, 109-118 (2017-09-26)

In this study, we investigated the potential of intradermal delivery of nanoparticulate vaccines to modulate the immune response of protein antigen using hollow microneedles. Four types of nanoparticles covering a broad range of physiochemical parameters, namely poly (lactic-co-glycolic) (PLGA) nanoparticles

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Global Trade Item Number

SKU	GTIN
P1223-100MG	04061832796208
P1223-500MG	04061832796246
P1223-25MG	04061832796222

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