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P1319

Thyrotropin releasing hormone

≥98% (HPLC), powder

Synonym(s):

L-Pyroglutamyl-L-histidyl-L-prolinamide, TRF, TRH, Thyroliberin, pGlu-His-Pro amide

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About This Item

Empirical Formula (Hill Notation):
C16H22N6O4
CAS Number:
24305-27-9
Molecular Weight:
362.38
UNSPSC Code:
51111800
NACRES:
NA.32
PubChem Substance ID:
24898185
EC Number:
246-143-4
Beilstein/REAXYS Number:
770238
MDL number:
MFCD00038640
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biological source

human

Quality Level

200

assay

≥98% (HPLC)

form

powder

mol wt

362.38

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

activity assay: suitable

impurities

22.6-23.8% Nitrogen, 51.9-54.1% carbon

solubility

water: 25 mg/mL, cloudy, colorless to faintly yellow

UniProt accession no.

P20396, P21761, P34981

storage temp.

−20°C

SMILES string

NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]3CCC(=O)N3

InChI

1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1

InChI key

XNSAINXGIQZQOO-SRVKXCTJSA-N

Gene Information

human ... TRH(7200), TRHR(7201)
mouse ... Trhr(22045)

General description

Research area: Cell Signaling
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.

Application

Thyrotropin-releasing hormone has been used as a media supplement to study its effects on stimulating the secretion of prolactin (PRL) from somatolactotroph GH3 cells by enzyme immunometric assay. It has also been used to study its effects on the regulation of energy homeostasis in the central nervous system (CNS) in response to essential amino-acid deprivation.

Biochem/physiol Actions

Thyrotropin releasing hormone (TRH) stimulates production and secretion of thyrotropin (TSH) and prolactin from the anterior pituitary.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.
Stimulates the production of thyrotropin (TSH) and its secretion from the anterior pituitary.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN4266
BCCM4621
BCCL6611
BCCH2796
BCCC9205

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Advantage of double labeled in situ hybridization for detecting the effects of glucocorticoids on the mRNAs of protooncogenes and neural peptides (TRH) in cultured hypothalamic neurons.
Luo LG and Jackson IM
Brain Research. Brain Research Protocols, 4(2), 201-208 (1999)
Vladimír Štrbák
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 50(1), 378-384 (2018-10-05)
Thyrotropin releasing hormone (TRH; pGlu-His-ProNH2) is expressed also in pancreatic β cells where it is colocalized in secretory granules with insulin. High perinatal changes of the TRH gene expression and TRH concentrations in rat pancreatic islets coincide with the perinatal
Laura Domínguez et al.
Brain, behavior and evolution, 71(3), 231-246 (2008-04-03)
To improve knowledge of the peptidergic systems in the brain of amphibians we have conducted a comparative analysis of the distribution of TRH immunoreactive cell bodies and fibers in three species of urodeles. Fiber labeling was observed in all main
View All Related Papers

Global Trade Item Number

SKUGTIN
P1319-250MG04061834354536
P1319-50MG04061834354543
P1319-1G04061826153178