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P148

4α-Phorbol 12-myristate 13-acetate

Name: 4α-Phorbol 12-myristate 13-acetate
Brand: SIGMA

solid, ≥95% (TLC)

Synonym(s):

4α-PMA

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About This Item

Empirical Formula (Hill Notation):

C₃₆H₅₆O₈

CAS Number:

63597-44-4

Molecular Weight:

616.83

NACRES:

NA.77

PubChem Substance ID:

24898203

UNSPSC Code:

12352211

MDL number:

MFCD00153860

Assay:

≥95% (TLC)

Form:

solid

Quality level:

100

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Quality Level

100

assay

≥95% (TLC)

form

solid

color

white

solubility

H₂O: ~2 μM, DMSO: soluble, ethanol: soluble

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(C)=O

InChI

1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34+,35-,36-/m1/s1

InChI key

PHEDXBVPIONUQT-LQLWEASQSA-N

General description

Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media.

Biochem/physiol Actions

Negative control for phorbol ester activation of protein kinase C.

Packaging

Sealed glass ampule.

Disclaimer

Photosensitive

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Role of TGF-beta1 in renal parenchymal scarring following childhood urinary tract infection.

Shirley A Cotton et al.

Kidney international, 61(1), 61-67 (2002-01-12)

Significant variability exists in the outcome of renal parenchymal inflammation following urinary tract infection (UTI) in childhood as some children experience renal parenchymal scarring (RPS) while others do not scar. Since TGF-beta1 is pro-fibrotic, we examined the role of this

4 Beta- and 4 alpha-12-O-tetradecanoylphorbol-13-acetate elicit arachidonate release from epidermal cells through different mechanisms.

S M Fischer et al.

Cancer research, 51(3), 850-856 (1991-02-01)

There is substantial evidence that the tumor promoter 4 beta-12-O-tetradecanoylphorbol-13-acetate (TPA) elicits enhanced arachidonic acid release and its metabolism to prostaglandins and lipoxygenase products in many cell types. The goal of this study was to determine whether 4 alpha-12-O-tetradecanoylphorbol-13-acetate (4

Phorbol ester enhancement of neurotransmitter release from rat brain synaptosomes.

R A Nichols et al.

Journal of neurochemistry, 48(2), 615-621 (1987-02-01)

Neurotransmitter release from rat brain synaptosomes was measured following pretreatment with various phorbol esters. Ca2+-dependent, evoked neurotransmitter release was increased by phorbol esters that were active in stimulating protein kinase C. Protein kinase C activation was demonstrated by increased incorporation

Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4.

Feng Xu et al.

British journal of pharmacology, 140(2), 413-421 (2003-09-13)

1. We investigated whether protein kinase C (PKC) activation stimulates Ca2+ entry in HEK 293 cells transfected with human TRPV4 cDNA and loaded with fura-2. 2. Phorbol 12-myristate 13-acetate (PMA), a PKC-activating phorbol ester, increased the intracellular Ca2+ concentration ([Ca2+]i)

Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).

Gautam Bhave et al.

Proceedings of the National Academy of Sciences of the United States of America, 100(21), 12480-12485 (2003-10-03)

Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the channel is activated by capsaicin. In addition, studies have suggested that phosphorylation by PKC might

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Global Trade Item Number

SKU	GTIN
P148-1MG	04061834355052

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