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P1537

Polyadenylic acid-Polyuridylic acid sodium salt

Name: Polyadenylic acid-Polyuridylic acid sodium salt
Brand: SIGMA

double-stranded homopolymer

Synonym(s):

Poly[A]•Poly[U]

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About This Item

CAS Number:

24936-38-7

UNSPSC Code:

41106305

NACRES:

NA.51

MDL number:

MFCD00131949

Form:

powder

Storage temp.:

−20°C

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Quality Level

200

form

powder

storage temp.

−20°C

SMILES string

[P](=O)(OC[C@H]3O[C@H]([C@@H]([C@@H]3O)O)[n]4c5ncnc(c5nc4)N)(O)O.[P](=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)N2C=CC(=O)NC2=O)(O)O

InChI

1S/C10H14N5O7P.C9H13N2O9P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1

InChI key

VGQHQOKIMNKUEF-ZLOOHWKQSA-N

Application

Polyadenylic acid-Polyuridylic acid (polyAU) is a double stranded homodimer studied for potential therapeutic activity, especially when coupled with radiotherapy. PolyA/U is used in comparative physiochemical studies with other duplex and single-stranded polymers such as poly-A and poly-U.

Other Notes

Double stranded homopolymer

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Polyadenylic-polyuridylic acid plus locoregional radiotherapy versus chemotherapy with CMF in operable breast cancer: a 14 year follow-up analysis of a randomized trial of the Fédération Nationale des Centres de Lutte contre le Cancer (FNCLCC).

A Laplanche et al.

Breast cancer research and treatment, 64(2), 189-191 (2001-02-24)

With a median follow-up of 14 years, the combination of polyadenylic-polyuridylic acid plus locoregional radiotherapy (257 patients) has significantly improved disease-free survival (p = 0.03) and significantly reduced the incidence of metastases (p = 0.04) when compared to CMF alone

Polyadenylic acid-polyuridylic acid (poly A : U) and experimental murine brucellosis. II. Macrophages as target cells of poly A : U in experimental brucellosis.

E D Madraso et al.

Immunology, 35(1), 77-84 (1978-07-01)

Direct effect of dsRNA mimetics on cancer cells induces endogenous IFN-β production capable of improving dendritic cell function.

Gerardo Gatti et al.

European journal of immunology, 43(7), 1849-1861 (2013-05-03)

Viral double-stranded RNA (dsRNA) mimetics have been explored in cancer immunotherapy to promote antitumoral immune response. Polyinosine-polycytidylic acid (poly I:C) and polyadenylic-polyuridylic acid (poly A:U) are synthetic analogs of viral dsRNA and strong inducers of type I interferon (IFN). We

Probing the binding of two sugar bearing anticancer agents aristololactam-β-(D)-glucoside and daunomycin to double stranded RNA polynucleotides: a combined spectroscopic and calorimetric study.

Abhi Das et al.

Molecular bioSystems, 8(7), 1958-1969 (2012-05-19)

The plant alkaloid aristololactam-β-d-glucoside and the anticancer chemotherapy drug daunomycin are two sugar bearing DNA binding antibiotics. The binding of these molecules to three double stranded ribonucleic acids, poly(A)·poly(U), poly(I)·poly(C) and poly(C)·poly(G), was studied using various biophysical techniques. Absorbance and

Thermodynamics of interactions of water-soluble porphyrins with RNA duplexes.

Ara A Ghazaryan et al.

Journal of the American Chemical Society, 128(6), 1914-1921 (2006-02-09)

We characterized the interactions of meso-tetrakis(4N-(2-hydroxyethyl)pyridinium-4-yl) porphyrin (TEtOHPyP4), meso-tetrakis(4N-allylpyridinium-4-yl) porphyrin (TAlPyP4), and meso-tetrakis(4N-metallylpyridinium-4-yl) porphyrin (TMetAlPyP4) with the poly(rA)poly(rU) and poly(rI)poly(rC) RNA duplexes between 18 and 45 degrees C by employing circular dichroism, light absorption, and fluorescence intensity spectroscopic measurements. Our

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Global Trade Item Number

SKU	GTIN
P1537-10MG	04061833289884

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