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Merck
CN

P1629

TWEEN® 60

nonionic detergent

Synonym(s):

Polyethylene glycol sorbitan monostearate, Polyoxyethylene sorbitan monostearate

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About This Item

CAS Number:
9005-67-8
UNSPSC Code:
12161900
NACRES:
NA.25
MDL number:
MFCD01780110

Key Documents

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SMILES string

O1C(C(C(C1)OCCO)OCCO)C(OCCO)COCCOC(=O)CCCCCCCCCCC

InChI

1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3

InChI key

HMFKFHLTUCJZJO-UHFFFAOYSA-N

mol wt

estimated mol wt 1309

composition

stearic acid, 40-60% , total stearic and palmitic acid, ≥90%

technique(s)

DNA extraction: suitable, RNA extraction: suitable, cell culture | mammalian: suitable, protein purification: suitable

CMC

27 mg/L

density

1.044 g/mL at 25 °C (lit.)

HLB

14.9

Quality Level

200

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General description

TWEEN 60 is a niosome.

Application

Polyethylene glycol sorbitan monostearate, or TWEEN 60, has been used in a study to assess encapsulation of functional lipophilic components in surfactant-based colloidal delivery systems. It has also been used in a study to investigate doxorubicin loaded magneto-niosomes for targeted drug delivery.

Legal Information

TWEEN is a registered trademark of Croda International PLC

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ7221
MKCZ0834
0000360285
0000469375
0000469375

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Lorena Tavano et al.
Colloids and surfaces. B, Biointerfaces, 102, 803-807 (2012-10-31)
In chemotherapy the magnetic drug targeting to a specific organ or tissue is proposed on the assumption that magnetic fields are harmless to biological systems. In this light we have vehiculated doxorubicin as model drug by novel magneto-niosomes in order
Ray F David et al.
Fungal genetics and biology : FG & B, 96, 25-32 (2016-10-22)
The plant pathogenic ascomycete Fusarium graminearum produces perithecia on corn and small grain residues. These perithecia forcibly discharge ascospores into the atmosphere. Little is known about the relationship among the strength of the perithecial wall, the age of the perithecium
Khalid Ziani et al.
Food chemistry, 134(2), 1106-1112 (2012-10-31)
The fabrication and stability of surfactant-based colloidal delivery systems (microemulsions and emulsions) suitable for encapsulation of lipophilic active agents (vitamins and flavours) was investigated. An emulsion titration method was used to study the influence of surfactant type (Tween 20, 60
Physicochemical properties and skin permeation of [TM="Span"] 60/Tween 60 niosomes of ellagic acid
Burapacheep, V., et al.
International Journal of Pharmaceutics, 432, 9-9 (2012)
Rafaela C Sartore et al.
PloS one, 6(6), e20667-e20667 (2011-06-16)
The existence of loss and gain of chromosomes, known as aneuploidy, has been previously described within the central nervous system. During development, at least one-third of neural progenitor cells (NPCs) are aneuploid. Notably, aneuploid NPCs may survive and functionally integrate

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