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Merck
CN

P208

PD 151,242

≥97%, powder

Synonym(s):

N-[N-[N-[(Hexahydro-1H-azepin-1-yl)carbonyl]-L-leucyl]-1-methyl-D-tryptophyl]-D-tyrosine

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About This Item

Empirical Formula (Hill Notation):
C34H45N5O6
CAS Number:
155561-67-4
Molecular Weight:
619.75
UNSPSC Code:
12352202
PubChem Substance ID:
329820115
MDL number:
MFCD00671787

Key Documents

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InChI

1S/C34H45N5O6/c1-22(2)18-27(37-34(45)39-16-8-4-5-9-17-39)31(41)35-28(20-24-21-38(3)30-11-7-6-10-26(24)30)32(42)36-29(33(43)44)19-23-12-14-25(40)15-13-23/h6-7,10-15,21-22,27-29,40H,4-5,8-9,16-20H2,1-3H3,(H,35,41)(H,36,42)(H,37,45)(H,43,44)/t27-,28+,29+/m0/s1

SMILES string

CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc2cn(C)c3ccccc23)C(=O)N[C@H](Cc4ccc(O)cc4)C(O)=O

InChI key

JVILFANCFWZBFU-ZGIBFIJWSA-N

assay

≥97%

form

powder

color

white

storage temp.

−20°C

Biochem/physiol Actions

Selective ETA endothelin receptor antagonist.

Disclaimer

Photosensitive

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
129H0921
129H09211

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Nadeshda Andreeva et al.
Folia microbiologica, 64(6), 867-873 (2019-04-03)
Inorganic polyphosphate is involved in architecture and functioning of yeast cell wall. The strain of Saccharomyces cerevisiae constitutively overexpressing acid phosphatase Pho5 was constructed for studying the Pho5 properties and its possible participation in polyphosphate metabolism. The parent strain was
Clara Di Filippo et al.
Journal of hypertension, 21(4), 747-753 (2003-03-27)
Chronically administered ouabain increases the content of ouabain in several brain areas that are closely related to central cardiovascular regulation. However, the pattern of central changes induced by chronic infusion of ouabain is not completely understood. To investigate whether chronic
A P Davenport et al.
British journal of pharmacology, 111(1), 4-6 (1994-01-01)
Our aim was to synthesize a new endothelin ETA selective radioligand, [125I]-PD151242 and characterize the compound in human vascular tissue. Binding of [125I]-PD151242 to sections of human aorta was time-dependent and reached equilibrium after 120 min at 23 degrees C
C R Bacon et al.
British journal of pharmacology, 117(5), 986-992 (1996-03-01)
1. ETA and ETB-selective and non-selective ligands were used to define the endothelin receptors in the media (vascular smooth muscle layer) of human aorta and coronary artery. Saturation experiments with iodinated endothelin-1 (ET-1), endothelin-2 and sarafotoxin 6b (S6b) identified high
C C Docherty et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 281(1), R261-R268 (2001-06-19)
At 110-111 days gestation, instrumented fetal sheep were administered saline or dexamethasone (2.2 microgram. kg(-1). h(-1) iv) for 48 h. Measurement of fetal blood pressure showed a greater increase in dexamethasone-treated (n = 6) compared with control (n = 5)
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