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P222

Pandinotoxin-Kα

>99%, powder

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About This Item

Empirical Formula (Hill Notation):
C169H267N53O48S7
CAS Number:
185529-64-0
Molecular Weight:
4033.71
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
MFCD01324942
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assay

>99%

form

powder

color

off-white

storage temp.

−20°C

General description

Pandinotoxin (PiTX)-Kα is a 35 amino acid peptide isolated from venom of the scorpion Pandinus imperaton. PiTX-Kβ and PiTXγ are other two members of pandinotoxin group. All the three pandinotoxins have structures similar to another scorpion toxin charybdotoxin (ChTX). The structure of PiTXs contains a β-sheet at the C- terminal end with three cysteines which is linked to the central α-helix by two disulfide bridges (C17-C35 and C13-C33) and to an extended amino-terminal fragment by the third disulfide bridge (C7-C28).

Biochem/physiol Actions

Pandinotoxin (PiTX) –Kα along with PiTX-Kβ and PiTXγ plays a vital role in blocking voltage-gated K+ channels.

Legal Information

Sold with the permission of University of Maryland.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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