P2363
Protein Kinase G II from rat
>90% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf9 cells, solution
Synonym(s):
Protein Kinase, 3′,5′-Cyclic GMP Dependent from rat
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About This Item
Specific activity:
~0.7 U/mg
Assay:
>90% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells
recombinant
expressed in baculovirus infected Sf9 cells
Quality Segment
assay
>90% (SDS-PAGE)
form
solution
specific activity
~0.7 U/mg
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
rat ... Prkg2(25523)
General description
Protein kinase, cGMP-dependent, type II (PRKG2), also known as type II cGMP-dependent protein kinase (cGK), is encoded by the gene mapped to human chromosome 4q13.1–q21.1.
Biochem/physiol Actions
Protein kinase, cGMP-dependent, type II (PRKG2) is implicated in the regulation of intestinal fluid balance in man. The encoded protein plays an essential role in proliferative to hypertrophic transition of growth plate chondrocytes during endochondral ossification. Loss of PRKG2 function is associated with the development of renal cysts, intellectual disability and speech defect. In rodent and bovine models, deletion of the gene leads to dwarfism.
Other Notes
One unit will phosphorylate one μmole of VASPtide (RRKVSKQE) per minute at pH 7.4
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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