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P2534

Poly-L-histidine hydrochloride

Name: Poly-<SC>L</SC>-histidine hydrochloride
Brand: SIGMA

mol wt ≥5000

Synonym(s):

L-Histidine homopolymer hydrochloride

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About This Item

CAS Number:

61857-39-4

UNSPSC Code:

12352209

PubChem Substance ID:

24898335

NACRES:

NA.26

MDL number:

MFCD00166382

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form

powder

Quality Level

200

mol wt

≥5000

color

white to very light yellow

storage temp.

−20°C

SMILES string

N[C@H](Cc1c[nH]cn1)C(O)=O

InChI key

HNDVDQJCIGZPNO-RXMQYKEDSA-N

Related Categories

Biochemicals

Cell Culture Supplements & Reagents

Chemistry & Biochemicals

Amino Acids – Building Blocks of Life Science

Analysis Note

Molecular weight by MALLS.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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pH-sensitive cationic polymer gene delivery vehicle: N-Ac-poly(L-histidine)-graft-poly(L-lysine) comb shaped polymer.

J M Benns et al.

Bioconjugate chemistry, 11(5), 637-645 (2000-09-20)

Advancing biotechnology spurs the development of new pharmaceutically engineered gene delivery vehicles. Poly(L-histidine) ¿PLH¿ has been shown to induce membrane fusion at endosomal pH values, whereas PLL has a well documented efficacy in polyplex formation. Therefore, N-Ac-poly(L-histidine)-graft-poly(L-lysine) ¿PLH-g-PLL¿ was synthesized

Dispersion of multi-wall carbon nanotubes in polyhistidine: characterization and analytical applications.

Pablo R Dalmasso et al.

Analytica chimica acta, 710, 58-64 (2011-11-30)

We report for the first time the use of polyhistidine (Polyhis) to efficiently disperse multiwall carbon nanotubes (MWCNTs). The optimum dispersion MWCNT-Polyhis was obtained by sonicating for 30 min 1.0 mg mL(-1) MWCNTs in 0.25 mg mL(-1) Polyhis solution prepared

Carboxymethyl poly(L-histidine) as a new pH-sensitive polypeptide to enhance polyplex gene delivery.

Asayama S, Sudo M, et al.

Molecular Pharmacology, 5, 898-901 (2008)

Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Global Trade Item Number

SKU	GTIN
P2534-10MG	04061832779386
P2534-100MG	04061832779379
P2534-500MG	04061832779409
P2534-25MG	04061832779393

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