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Merck
CN

P2534

Poly-L-histidine hydrochloride

mol wt ≥5000

Synonym(s):

L-Histidine homopolymer hydrochloride

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About This Item

CAS Number:
61857-39-4
UNSPSC Code:
12352209
PubChem Substance ID:
24898335
NACRES:
NA.26
MDL number:
MFCD00166382

Key Documents

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Product Name

Poly-L-histidine hydrochloride, mol wt ≥5000

InChI key

HNDVDQJCIGZPNO-RXMQYKEDSA-N

SMILES string

N[C@H](Cc1c[nH]cn1)C(O)=O

form

powder

mol wt

≥5000

color

white to very light yellow

storage temp.

−20°C

Quality Level

200

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Analysis Note

Molecular weight by MALLS.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLBS5352
SLBL7217V
SLBH6325V
110M5005V
110M5005

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Pablo R Dalmasso et al.
Analytica chimica acta, 710, 58-64 (2011-11-30)
We report for the first time the use of polyhistidine (Polyhis) to efficiently disperse multiwall carbon nanotubes (MWCNTs). The optimum dispersion MWCNT-Polyhis was obtained by sonicating for 30 min 1.0 mg mL(-1) MWCNTs in 0.25 mg mL(-1) Polyhis solution prepared
J M Benns et al.
Bioconjugate chemistry, 11(5), 637-645 (2000-09-20)
Advancing biotechnology spurs the development of new pharmaceutically engineered gene delivery vehicles. Poly(L-histidine) ¿PLH¿ has been shown to induce membrane fusion at endosomal pH values, whereas PLL has a well documented efficacy in polyplex formation. Therefore, N-Ac-poly(L-histidine)-graft-poly(L-lysine) ¿PLH-g-PLL¿ was synthesized
Carboxymethyl poly(L-histidine) as a new pH-sensitive polypeptide to enhance polyplex gene delivery.
Asayama S, Sudo M, et al.
Molecular Pharmacology, 5, 898-901 (2008)

Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

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