P2745
Protein Phosphatase Inhibitor 1 human
Synonym(s):
Inhibitor 1 human
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About This Item
biological source
human
Quality Level
recombinant
expressed in E. coli
assay
>95% (SDS-PAGE)
form
solution
mol wt
~31 kDa, apparent mol wt ~27 kDa
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PPP1R1A(5502), PPP1R8(5511)
Application
This protein phosphatase inhibitor 1 is suitable for use as a substrate to identify novel phosphatases and kinases that modulate protein phosphatase inhibitor 1 activity. This product is also suitable for use in affinity pull-down binding studies. Protein Phosphatase Inhibitor 1 human has been used as a component in the sucrose cell lysis buffer. It has also been used for intraperitoneal injection of mice prior to natterins or saline treatment in pharmacological intervention studies.
Biochem/physiol Actions
Intimately involved in glycogen metabolism as an inhibitor of phosphorylase phosphatase, the enzyme responsible for conversion of phosphorylase b to phosphorylase a. Inhibition is invoked only upon phosphorylation by a cAMP-dependent protein kinase.
Physical form
Supplied as a solution in 50 mM Tris-HCl, pH 7.0, containing 0.1 mM PMSF, 14 mM 2-mercaptoethanol, and 10% glycerol
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Related Content
Instructions
Inhibition of Inflammatory Changes in Human Myometrial Cells by Cell Penetrating Peptide and Small Molecule Inhibitors of NF kappaB
Gurney LRI, et al.
Frontiers in Immunology, 9, 2966-2966 (2018)
Zlatka Plavec et al.
Viruses, 14(9) (2022-09-24)
Severe acute respiratory syndrome coronavirus-2 is the causative agent of COVID-19. During the pandemic of 2019-2022, at least 500 million have been infected and over 6.3 million people have died from COVID-19. The virus is pleomorphic, and due to its
Xiaonan Liu et al.
Molecular systems biology, 17(11), e10396-e10396 (2021-10-29)
Treatment options for COVID-19, caused by SARS-CoV-2, remain limited. Understanding viral pathogenesis at the molecular level is critical to develop effective therapy. Some recent studies have explored SARS-CoV-2-host interactomes and provided great resources for understanding viral replication. However, host proteins
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P2745-1UG | 04061838071828 |