P2745
Protein Phosphatase Inhibitor 1 human
Synonym(s):
Inhibitor 1 human
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About This Item
biological source
human
Quality Segment
recombinant
expressed in E. coli
assay
>95% (SDS-PAGE)
form
solution
mol wt
~31 kDa, apparent mol wt ~27 kDa
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PPP1R1A(5502), PPP1R8(5511)
Application
This protein phosphatase inhibitor 1 is suitable for use as a substrate to identify novel phosphatases and kinases that modulate protein phosphatase inhibitor 1 activity. This product is also suitable for use in affinity pull-down binding studies. Protein Phosphatase Inhibitor 1 human has been used as a component in the sucrose cell lysis buffer. It has also been used for intraperitoneal injection of mice prior to natterins or saline treatment in pharmacological intervention studies.
Biochem/physiol Actions
Intimately involved in glycogen metabolism as an inhibitor of phosphorylase phosphatase, the enzyme responsible for conversion of phosphorylase b to phosphorylase a. Inhibition is invoked only upon phosphorylation by a cAMP-dependent protein kinase.
Physical form
Supplied as a solution in 50 mM Tris-HCl, pH 7.0, containing 0.1 mM PMSF, 14 mM 2-mercaptoethanol, and 10% glycerol
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Skin Sens. 1
Storage Class
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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