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P2850

Phosphatase Inhibitor Cocktail 1

Name: Phosphatase Inhibitor Cocktail 1
Brand: SIGMA

DMSO solution, mixture of inhibitors

Synonym(s):

Phosphatase Inhibitor

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About This Item

UNSPSC Code:

12352200

EC Number:

200-664-3

NACRES:

NA.54

Form:

DMSO solution

Quality level:

300

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Product Name

Phosphatase Inhibitor Cocktail 1, DMSO solution

form

DMSO solution

Quality Level

300

shipped in

wet ice

storage temp.

2-8°C

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

General description

Phosphatase Inhibitor Cocktail 1 includes a mixture of inhibitors that will inhibit the L-isozymes of alkaline phosphatase as well as serine/threonine protein phosphatases such as PP1 and PP2A. This product contains microcystinLR, cantharidin, and (−)-p-bromotetramisole. Phosphatase Inhibitor Cocktail 1 has been replaced with P0044.

Application

Phosphatase Inhibitor Cocktail 1 has been used in nuclear protein isolation and electrophoretic mobility shift assay (EMSA) for catenin activation. It has also been used in western blot analysis.

Biochem/physiol Actions

Phosphatases are active regulators of a number of important biological processes. Inhibition of phosphatases by small molecules is useful to study its biological role.

Preparation Note

Recommended usage is a 100-fold dilution.

Analysis Note

Tested on cell extracts from animal tissues such as bovine liver, human placenta, and rabbit muscle, as well as on extracts from A431 and Jurkat cell lines.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F

flash_point_c

87 °C

Regulatory Information

高风险级别生物产品--毒素类产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000469070

0000317618

0000317617

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Virulent Mycobacterium tuberculosis (Mtb) triggers necrosis in host Mϕ, which is essential for successful pathogenesis in tuberculosis. Here we demonstrate that necrosis of Mtb-infected Mϕ is dependent on the action of the cytosolic Receptor Interacting Protein Kinase 3 (RIPK3) and

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Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis.

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Proceedings of the National Academy of Sciences of the USA, 103(28), 10606-10611 (2006)

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Global Trade Item Number

SKU	GTIN
P2850-5ML	04061838164469
P2850-1ML	04061838355430
P2850-0.3ML	04061837898747

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