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Merck
CN

P2906

Poly(ethylene glycol)

Hybri-Max™, mol wt 3,000-3,700, waxy solid, BioReagent, suitable for hybridoma

Synonym(s):

Polyethylene glycol, PEG

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About This Item

Linear Formula:
H(OCH2CH2)nOH
CAS Number:
25322-68-3
NACRES:
NA.75
PubChem Substance ID:
24898372
UNSPSC Code:
12161902
MDL number:
MFCD00081839

Key Documents

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Product Name

Poly(ethylene glycol), Hybri-Max™, mol wt 3,000-3,700, waxy solid, BioReagent, suitable for hybridoma

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

SMILES string

C(CO)O

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

biological source

synthetic (organic)

grade

Hybri-Max™

sterility

autoclaved

product line

BioReagent

form

waxy solid

mol wt

3,000-3,700

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

Quality Level

200

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Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

Application

Poly(ethylene glycol) has been used in the production of monoclonal antibodies.
Recommended for cell fusion.

General description

Poly(ethylene glycol) (PEG) is a non-ionic hydrophilic polymer and is available in different molecular weights. It either exists in the form of a linear or branched structure. It aids in the purification and crystal growth of proteins and nucleic acids. PEG along with dextran is used to achieve an aqueous polymer two-phase system, which is essential for the purification of biological materials. It permits cell fusion through its interaction with the cell membrane.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

281.5 °F - closed cup

flash_point_c

138.6 °C - closed cup

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000403262
0000405183
0000403262
0000405183
0000282382

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Harris JM
Poly(Ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications (2013)
Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody
Yu S, et al.
Neuroscience journal, 145(2), 539-555 (2007)
Agathe Dubuisson et al.
Cell death & disease, 10(2), 101-101 (2019-02-06)
Development of therapeutic antibodies in oncology has attracted much interest in the past decades. More than 30 of them have been approved and are being used to treat patients suffering from cancer. Despite encouraging results, and albeit most clinical trials
I L Konorova et al.
Patologicheskaia fiziologiia i eksperimental'naia terapiia, (4)(4), 7-9 (1991-07-01)
The search for antiaggregatory compounds is undertaken, as a rule, under in vitro conditions which do not reflect the dynamics of the real process. The present work deals with study of the peculiarities of the development of the collagen induced
P I Polimeni et al.
Journal of cardiovascular pharmacology, 14(3), 374-380 (1989-09-01)
The acute hemodynamic effects of an intravenously (i.v.) injected poly(ethylene oxide), Polyox WSR N-60K (dose 50 mg/kg), were studied in the open-chest rat anesthetized with sodium pentobarbital. The injectate is one of four drag-reducing polymers known to augment in vitro
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