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P3076

Platelet-Derived Growth Factor-AA human

Name: Platelet-Derived Growth Factor-AA human
Brand: SIGMA

PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

PDGF−AA

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00081862

Biological source:

human

Recombinant:

expressed in E. coli

Assay:

≥98% (SDS-PAGE and HPLC)

Form:

lyophilized powder

Mol wt:

28.5 kDa (containing 250 amino acid residues)

Impurities:

<1 EU/μg

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biological source

human

Quality Level

100

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

potency

≤1.0-3.0 ng/mL ED₅₀

quality

endotoxin tested

mol wt

28.5 kDa (containing 250 amino acid residues)

packaging

pkg of 10 μg, pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

<1 EU/μg

UniProt accession no.

P04085

storage temp.

−20°C

Gene Information

human ... PDGFRA(5154)

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Related Categories

Cell Culture & Analysis

Cell Culture Supplements & Reagents

Growth Factors and Cytokines

Molecular Biology & Functional Genomics

General description

Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages. The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3. PDGF is structurally and functionally related to vascular endothelial growth factors.

Biochem/physiol Actions

Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis. PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors. Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.

Physical form

Sterile-filtered through a 0.2 μm filter. Lyophilized with 10 mM acetic acid.

Analysis Note

The biological activity is measured by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells.

Other Notes

Homodimer of the A chain of human PDGF.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Role of platelet-derived growth factors in physiology and medicine.

Andrae J, et al.

Genes & Development, 22.10, 1276-1312 (2008)

Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non?small cell lung carcinomas.

Shikada Y, et al.

Cancer Research, 65.16, 7241-7248 (2005)

Clinical Findings Associated with a De Novo Partial Trisomy 10p11. 22p15. 3 and Monosomy 7p22. 3 Detected by Chromosomal Microarray Analysis.

Kohannim O, et al.

Case Reports in Genetics, 2011 (2011)

Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells.

Luana Abballe et al.

Frontiers in pediatrics, 6, 315-315 (2018-11-18)

Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells

Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension.

Perros F, et al.

American Journal of Respiratory and Critical Care Medicine, 178.1, 81-88 (2008)

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Articles

Platelet Derived Growth Factors (PDGF)

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.

血小板衍生生长因子(PDGF)

血小板衍生生长因子是在哺乳动物血清中发现的主要有丝分裂原，在血栓形成过程中从血小板释放。

Global Trade Item Number

SKU	GTIN
P3076-10UG	04061834367154
P3076-50UG	04061834367161

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