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P3635

5β-Pregnane-3α,20α-diol glucuronide

Name: 5&#946;-Pregnane-3&#945;,20&#945;-diol glucuronide
Brand: SIGMA

≥98.00% (TLC), powder, progesterone metabolite

Synonym(s):

P3G, PDG, Pn3-G, Pregnanediol-3a-glucuronide, Pregnanediol-glucuronide, 3α,20α-Dihydroxy-5β-pregnane 3-glucuronide

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About This Item

Empirical Formula (Hill Notation):

C₂₇H₄₄O₈

CAS Number:

1852-49-9

Molecular Weight:

496.63

UNSPSC Code:

51111800

PubChem Substance ID:

24898430

NACRES:

NA.77

MDL number:

MFCD00056522

Assay:

≥98.00% (TLC)

Form:

powder

Quality level:

200

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Properties

Product Name

5β-Pregnane-3α,20α-diol glucuronide,

sterility

non-sterile

Quality Level

200

assay

≥98.00% (TLC)

form

powder

technique(s)

enzyme immunoassay: suitable

solubility

ethanol: 20 mg/mL, clear, colorless

shipped in

ambient

storage temp.

−20°C

SMILES string

CC(O)C1CCC2C3CCC4CC(CCC4(C)C3CCC12C)OC5OC(C(O)C(O)C5O)C(O)=O

InChI

1S/C27H44O8/c1-13(28)17-6-7-18-16-5-4-14-12-15(8-10-26(14,2)19(16)9-11-27(17,18)3)34-25-22(31)20(29)21(30)23(35-25)24(32)33/h13-23,25,28-31H,4-12H2,1-3H3,(H,32,33)

InChI key

ZFFFJLDTCLJDHL-UHFFFAOYSA-N

Description

General description

5β-Pregnane-3α,20α-diol glucuronide is a progesterone metabolite predominant in urine, during pregnancy. Presence of 5β-Pregnane-3α,20α-diol glucuronide in the urine indicates pregnancy, but it might also account for pseudopregnancy. It is useful in predicting the delivery time/end of pseudopregnancy.

Urinary pregnanediol glucuronide (PdG) seems to serve as an effective clinical marker for monitoring progesterone supplementation. PdG, along with other urinary metabolites such as luteinizing hormone (LH), follicle stimulating hormone (FSH), and estrone glucuronide (ElG), exhibit a strong association with ovarian excretion rates and demonstrate a high correlation with serum reproductive hormones. As a result, they can be used interchangeably to effectively monitor ovarian steroidogenesis.

Application

5β-Pregnane-3α,20α-diol glucuronide has been used in a cross-sectional analysis of hormone levels. It has also been used as a standard to measure estradiol-17β, pregnanediol-glucuronide (PdG) by a double-antibody enzyme immunoassay.

5β-Pregnane-3α,20α-diol glucuronide has been used in steroid enzyme immunoassay.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Partial recovery of luteal function after bariatric surgery in obese women.

Dana Rochester et al.

Fertility and sterility, 92(4), 1410-1415 (2008-10-03)

To determine whether obesity-related reproductive endocrine abnormalities in ovulatory women are reversible with weight loss. Observational cohort study. Healthy volunteers in an academic research environment. Women aged 18-48 years with regular menstrual cycles 21-40 days and a body mass index

Reproductive life history traits of female orangutans (Pongo spp.).

Robert W Shumaker et al.

Interdisciplinary topics in gerontology, 36, 147-161 (2008-06-05)

Data from wild populations demonstrate that orangutans have the slowest life history of all the great apes. In this chapter, we provide an overview of reproduction and life history traits of female orangutans in the wild and captivity. This comparison

Meena P Desai et al.

Journal of clinical laboratory analysis, 21(2), 55-60 (2007-03-28)

This study characterizes age-related changes in bone turnover markers in relation to ovarian hormones. The data (N = 236) were divided into 5-year age bands and three groups: premenopausal (Group I, N = 139), perimenopausal (Group II, N = 30)

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Global Trade Item Number

SKU	GTIN
P3635-25MG	04061832851150
P3635-5MG	04061834369011