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P3644

L-α-Phosphatidylcholine

Name: <SC>L</SC>-α-Phosphatidylcholine
Brand: SIGMA

from soybean, Type IV-S, ≥30% (enzymatic)

Synonym(s):

1,2-Diacyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, L-α-Lecithin, Azolectin, PC

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About This Item

CAS Number:

8002-43-5

UNSPSC Code:

51321705

NACRES:

NA.25

EC Number:

232-307-2

Beilstein/REAXYS Number:

5209585

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Properties

biological source

soybean

Quality Segment

200

type

Type IV-S

form

solid

concentration

≥30% (enzymatic)

solubility

chloroform: soluble 100 mg/mL, clear to slightly hazy, yellow to orange

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

SMILES string

[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCCCCCCCCCC)OCC[N+](C)(C)C

InChI

1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1

InChI key

JLPULHDHAOZNQI-ZTIMHPMXSA-N

Description

Application

L-α-Phosphatidylcholine is suitable for use:

as a component of human erythroid massive amplification culture (HEMA^def) medium for clinical expansion of human erythroblasts
in the chloride efflux assay to examine the chloride permeability of lipid vesicles conferred by soluble CLIC1
in an assay to measure solubilized wax synthase activity
as a component of buffer A used for the resuspension of the cholate-solubilized catalytic unit of adenylate cyclase
as a cryoprotectant for freezing ruminant sperm
as a substrate for the estimation of phospholipase activity
to make liposomes to assess their efficiency of recruitment of ARF (ADP ribosylation factor) and AP-1 (adaptor protein)
in the preparation of the isolated catalytic unit of soluble adenylate cyclase

Biochem/physiol Actions

Phosphatidylcholine is the major membrane phospholipid in eukaryotic cells, forming the structural component of these membranes. It also serves as a reservoir for several lipid messengers and a source for several bioactive lipids such as, lysophosphatidylcholine, phosphatidic acid, diacylglycerol, lysophosphatidylcholine, platelet activating factor, and arachidonic acid.

A major structural phospholipid in brain, comprising approx. 15% of total lipid; primarily localized to gray matter.

Preparation Note

Purified from P 5638

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Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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