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P3892

Poly-L-arginine hydrochloride

Name: Poly-<SC>L</SC>-arginine hydrochloride
Brand: SIGMA

suitable for bioconjugations, Mol wt >70,000

Synonym(s):

L-Arginine homopolymer hydrochloride

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About This Item

CAS Number:

26982-20-7

UNSPSC Code:

12352209

PubChem Substance ID:

24898466

NACRES:

NA.26

MDL number:

MFCD00166393

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Product Name

Poly-L-arginine hydrochloride, mol wt >70,000

form

powder or solid

Quality Level

200

mol wt

>70,000

technique(s)

bioconjugation: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

InChI key

PQEISBBDIRAKGR-LFELFHSZSA-N

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Related Categories

Biochemicals

Cell Culture Supplements & Reagents

Amino Acids – Building Blocks of Life Science

Application

Poly-L-arginine hydrochloride has been used:

as polyelectrolyte solution in the synthesis of biodegradable capsules
as layer constituent, in the preparation of layer by layer (LbL) assembly of multilayer biodegradable shells
in assay for the determination of binding activity of C-reactive protein for polycationic ligands

Biochem/physiol Actions

Poly-L-arginine (PLA) possesses anti-bacterial activity. It has a greater capacity to enhance membrane permeability. PLA at lower concentration enhances cell proliferation and at higher concentration acts as antiproliferative agent.

Analysis Note

Contains 3% or less ornithine residue by TLC.

Molecular weight based on viscosity of precursor poly-L-ornithine.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Poly-L-arginine: Enhancing Cytotoxicity and Cellular Uptake of Doxorubicin and Necrotic Cell Death

Movafegh B, et al.

Anticancer Agents in Medicinal Chemistry, 18(10), 1448-1456 (2018)

Interaction of Calcium-bound C-reactive Protein with Fibronectin Is Controlled by pH IN VIVO IMPLICATIONS

Suresh MV, et al.

Test, 279(50), 52552-52557 (2004)

Antibacterial activity of poly-l-arginine under different conditions

Sepahi M , et al.

Iranian Journal of Microbiology, 9(2), 103-103 (2017)

NIR-light triggered delivery of macromolecules into the cytosol

Carregal-Romero S, et al.

Journal of Controlled Release : Official Journal of the Controlled Release Society, 159(1), 120-127 (2012)

Multilayered Magnetic Nanobeads for the Delivery of Peptides Molecules Triggered by Intracellular Proteases

Quarta A, et al.

ACS Applied Materials & Interfaces, 9(40), 35095-35104 (2017)

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Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Global Trade Item Number

SKU	GTIN
P3892-50MG	04061832779713
P3892-100MG	04061835547579
P3892-10MG	04061832779706

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