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P4194

DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol

Name: <SC>DL</SC>-<I>threo</I>-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol
Brand: SIGMA

98%

Synonym(s):

(±)-PPMP

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₅₀N₂O₃ · HCl

CAS Number:

149022-18-4

Molecular Weight:

511.18

NACRES:

NA.25

PubChem Substance ID:

24898512

UNSPSC Code:

12352211

MDL number:

MFCD00211157

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Properties

Quality Level

100

assay

98%

form

powder

lipid type

phosphoglycerides

storage temp.

2-8°C

SMILES string

CCCCCCCCCCCCCCCC(=O)N[C@H](CN1CCOCC1)[C@H](O)c2ccccc2

InChI

1S/C29H50N2O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-17-20-28(32)30-27(25-31-21-23-34-24-22-31)29(33)26-18-15-14-16-19-26/h14-16,18-19,27,29,33H,2-13,17,20-25H2,1H3,(H,30,32)/t27-,29-/m1/s1

InChI key

OFBANDBMHLEMFA-XRKRLSELSA-N

Description

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Improved inhibitors of glucosylceramide synthase.

A Abe et al.

Journal of biochemistry, 111(2), 191-196 (1992-02-01)

An inhibitor of glucosylceramide (GlcCer) synthase, 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), has been reported to deplete cells and mice of their glucosphingolipids. This inhibitor has proved useful for the elucidation of the many functions of this lipid family [reviewed by Radin, N.S. &

Virginia Sara Grancieri do Amaral et al.

International journal of molecular sciences, 21(8) (2020-04-16)

Psd1 is a pea plant defensin which can be actively expressed in Pichia pastoris and shows broad antifungal activity. This activity is dependent on fungal membrane glucosylceramide (GlcCer), which is also important for its internalization, nuclear localization, and endoreduplication. Certain

Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule.

Tomasz B Owczarek et al.

PloS one, 8(12), e84191-e84191 (2014-01-07)

It was recently proposed that UDP-galactose:ceramide galactosyltransferase (UGT8), enzyme responsible for synthesis of galactosylceramide (GalCer), is a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of lung metastases in breast cancer. To further reveal the

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Global Trade Item Number

SKU	GTIN
P4194-5MG	04061832796710