P4380
Protamine sulfate
powder
Synonym(s):
Salmine, Salmine from salmon
Product Name
Protamine sulfate salt from salmon, Grade II
biological source
fish (salmon)
type
Grade II
form
powder
color
white to off-white
solubility
6 M HCl: 25 mg/mL, clear, colorless to light yellow
Quality Level
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General description
Protamine sulfate (PS), a polycationic, positively charged protein is mostly made up of poly(l-arginine). It is obtained from salmon sperm protein.
Application
May be used for the removal of DNA from protein samples or for the purification of DNA binding proteins. It may be used as an alternative to polybrene in retroviral-mediated gene transfer.
Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine sulfate salt from salmon has been used in the generation of protamine silica nanocomposites.
Biochem/physiol Actions
Protamine sulfate is a small cationic protein that binds and precipitates DNA. Neutralizes the anticoagulant activity of heparin. Inhibits lipoprotein lipase.
Protamine sulfate is highly preferred in cardiovascular surgical procedures to reverse the anticoagulant properties of heparin. It is used for biomedical and biotechnological applications due to its biodegradablity.
Analysis Note
May contain insolubles as well as histones.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
低风险生物材料
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Blood Component and Pharmacologic Therapy for Hemostatic Disorders
Consultative Hemostasis and Thrombosis, 540-572 (2019)
Implications of protein-and Peptide-based nanoparticles as potential vehicles for anticancer drugs
Advances in Protein Chemistry and Structural Biology, 98, 169-221 (2015)
Jacob F Warner et al.
Methods in molecular biology (Clifton, N.J.), 1128, 211-221 (2014-02-26)
The Hedgehog pathway has been shown to be an important developmental signaling pathway in many organisms (Ingham and McMahon. Genes Dev 15:3059-3087, 2001). Recently that work has been extended to developing echinoderm embryos (Walton et al. Dev Biol 331(1):26-37, 2009).
Protamine-templated biomimetic hybrid capsules: efficient and stable carrier for enzyme encapsulation
Zhang Y, et al.
Chemistry of Materials, 20(3), 1041-1048 (2007)
TLR4 activation by lysozyme induces pain without inflammation.
Yadav, et al.
Frontiers in Immunology, 14, 1065226-1065226 (2023)
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