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Merck
CN

P4498

Pravastatin sodium salt hydrate

synthetic (organic), ≥98% (HPLC), HMG-CoA reductase inhibitor, powder

Synonym(s):

(βR, δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β, δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic acid sodium hydrate, Eptastatin sodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):
C23H35O7Na · xH2O
CAS Number:
81131-70-6
Molecular Weight:
446.51 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329820206
NACRES:
NA.77
MDL number:
MFCD00887601

Key Documents

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Product Name

Pravastatin sodium salt hydrate, ≥98% (HPLC), powder

color

white

SMILES string

[Na+].[H][C@@](O)(CC[C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@H](OC(=O)[C@@H](C)CC)[C@]12[H])C[C@@H](O)CC([O-])=O

InChI key

VWBQYTRBTXKKOG-IYNICTALSA-M

InChI

1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1

biological source

synthetic (organic)

assay

≥98% (HPLC)

form

powder

mp

171.2-173 °C

solubility

H2O: >10 mg/mL

originator

Bristol-Myers Squibb

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... HMGCR(3156)

Related Categories

Application

Pravastatin sodium salt hydrate has been used in the enzymatic method to measure mevalonic acid in serum.

Biochem/physiol Actions

Competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Inhibits cholesterol synthesis in vivo (Ki ~1 nM).
Pravastatin sodium is a competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Pravastatin sodium is an orally effective hypocholesterolaemic agent which is structurally similar to lovastatin and compactin.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000212710
0000212710
0000186357
0000147645
0000186357

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S M Singhvi et al.
British journal of clinical pharmacology, 29(2), 239-243 (1990-02-01)
Pravastatin sodium, a competitive inhibitor of HMG-CoA reductase, is a new orally effective hypocholesterolaemic agent. In a two-way crossover study, eight healthy male subjects each received an intravenous and an oral dose of [14C]-pravastatin sodium. The oral absorption of [14C]
Kevin F Erickson et al.
Journal of the American College of Cardiology, 61(12), 1250-1258 (2013-03-19)
The authors sought to evaluate the cost-effectiveness of statins for primary prevention of myocardial infarction (MI) and stroke in patients with chronic kidney disease (CKD). Patients with CKD have an elevated risk of MI and stroke. Although HMG Co-A reductase
Statins for treating stable angina: can statins improve the plaque morphology and angina?
Cheol Whan Lee et al.
Future cardiology, 9(2), 155-158 (2013-03-08)
Ashley J Bauer et al.
Hypertension (Dallas, Tex. : 1979), 61(5), 1103-1110 (2013-03-06)
Preeclampsia is a pregnancy-specific condition characterized by an imbalance of circulating angiogenic factors and new-onset hypertension. Although current treatment options are limited, recent studies suggest that pravastatin may improve angiogenic profile and reduce blood pressure in preeclampsia. We hypothesized pravastatin
[Dermatomyositis].
Sylvain Glitho et al.
La Revue du praticien, 63(5), 626-626 (2013-06-26)
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