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P4510

Poly-ε-Cbz-L-lysine

Name: Poly-ε-Cbz-<SC>L</SC>-lysine
Brand: SIGMA

mol wt 500-4,000

Synonym(s):

N⁶-[(phenylmethoxy)carbonyl]-L-lysine homopolymer

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About This Item

CAS Number:

25931-47-9

UNSPSC Code:

12352209

NACRES:

NA.26

MDL number:

MFCD00166378

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Properties

form

powder

Quality Level

200

mol wt

500-4,000

color

white

storage temp.

−20°C

SMILES string

[N+H3][C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)[O-]

InChI

1S/C14H20N2O4/c15-12(13(17)18)8-4-5-9-16-14(19)20-10-11-6-2-1-3-7-11/h1-3,6-7,12H,4-5,8-10,15H2,(H,16,19)(H,17,18)/t12-/m0/s1

InChI key

CKGCFBNYQJDIGS-LBPRGKRZSA-N

Description

Application

Transfection by polyethyleneimine-coated microspheres.: This study explores the use of Poly-e-Cbz-L-lysine in coating microspheres with polyethyleneimine for enhanced cell transfection, demonstrating improved efficiency and potential applications in gene therapy (Manuel WS et al., 2001).

Transfection of cells mediated by biodegradable polymer materials with surface-bound polyethyleneimine.: The research focuses on biodegradable polymer materials, including Poly-e-Cbz-L-lysine, for cell transfection, highlighting their biodegradability and effectiveness in delivering genetic material (Zheng J et al., 2000).

Production of microspheres with surface amino groups from blends of Poly(Lactide-co-glycolide) and Poly(epsilon-CBZ-L-lysine) and use for encapsulation.: This paper discusses the creation of microspheres with surface amino groups using blends of Poly-e-Cbz-L-lysine, which are then used for encapsulating active agents, indicating applications in drug delivery systems (Zheng J et al., 1999).

Modification of materials formed from poly(L-lactic acid) to enable covalent binding of biopolymers: application to high-density three-dimensional cell culture in foams with attached collagen.: The study examines the modification of poly(L-lactic acid) materials with Poly-e-Cbz-L-lysine to covalently bind biopolymers, facilitating high-density 3D cell culture applications (Zheng J et al., 1998).

Analysis Note

Molecular weight by Electrospray Mass-Spectrometry

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Transfection by polyethyleneimine-coated microspheres.

W S Manuel et al.

Journal of drug targeting, 9(1), 15-22 (2001-05-30)

Polyethyleneimine (PEI) can be used as a DNA delivery mechanism in cell culture and in vivo. Cells can be transfected by using surface-bound PEI, as well as by PEI/DNA microparticles. In the present experiments we extended these observations by preparing

Engineering Intravenously Administered Nanoparticles to Reduce Infusion Reaction and Stop Bleeding in a Large Animal Model of Trauma.

Chimdiya Onwukwe et al.

Bioconjugate chemistry, 29(7), 2436-2447 (2018-07-03)

Bleeding from traumatic injury is the leading cause of death for young people across the world, but interventions are lacking. While many agents have shown promise in small animal models, translating the work to large animal models has been exceptionally

Production of microspheres with surface amino groups from blends of Poly(Lactide-co-glycolide) and Poly(epsilon-CBZ-L-lysine) and use for encapsulation.

J Zheng et al.

Biotechnology progress, 15(4), 763-767 (1999-08-12)

Microspheres were formed from blends of the biodegradable polymer poly(DL-lactic-co-glycolic acid) (PLGA) together with poly(epsilon-CBZ-L-lysine) (PCBZL) by a double-emulsification/solvent evaporation technique. The size of the microspheres formed by this method was dependent both on the total concentration of the polymers

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Global Trade Item Number

SKU	GTIN
P4510-1G	04061834374688