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P4620

PD 146176

≥98% (HPLC), solid

Synonym(s):

6,11-Dihydro[1]benzothiopyrano[4,3-b]indole

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About This Item

Empirical Formula (Hill Notation):
C15H11NS
CAS Number:
4079-26-9
Molecular Weight:
237.32
NACRES:
NA.77
PubChem Substance ID:
24724579
UNSPSC Code:
51111800
MDL number:
MFCD05664738
Assay:
≥98% (HPLC)
Form:
solid
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Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

white to beige

solubility

DMSO: soluble >10 mg/mL, H2O: insoluble

SMILES string

C1Sc2ccccc2-c3[nH]c4ccccc4c13

InChI

1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2

InChI key

ZGOOPZVQMLHPFM-UHFFFAOYSA-N

Gene Information

human ... ALOX15(246)
mouse ... ALOX15(11687)
rat ... ALOX15(81639)

Application

PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue.

Biochem/physiol Actions

PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme.
15-Lipoxygenase inhibitor

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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