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P4871

Sigma-Aldrich

Anti-Purinergic Receptor P2Y12 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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Synonym(s):
Anti-ADPG-R, Anti-BDPLT8, Anti-HORK3, Anti-P2T(AC), Anti-P2Y(12)R, Anti-P2Y(AC), Anti-P2Y(ADP), Anti-P2Y(cyc), Anti-P2Y12
MDL number:
MFCD04975335
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human, mouse, rat

technique(s)

immunohistochemistry: suitable using mouse brain sections
western blot: 1:200 using rat brain membranes or human platelets

UniProt accession no.

Q9H244

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... P2RY12(64805)
mouse ... P2ry12(70839)
rat ... P2ry12(64803)

General description

Purinergic receptor or platelet adenosine 5′-diphosphate (ADP) receptor P2Y12 is a G-protein-coupled receptor. The gene encoding it is localized on human chromosome 3q25.1.

Immunogen

peptide corresponding to amino acid residues 125-142 of human P2Y12. This epitope is highly homologous in rat and mouse (16/18 residues identical).

Application

Anti-Purinergic Receptor P2Y12 antibody produced in rabbit has been used in Western blotting.

Biochem/physiol Actions

Purinergic receptor or platelet adenosine 5′-diphosphate (ADP) receptor P2Y12 has a role in platelet aggregation induced by ADP. Dysfunctional mutations in the protein have been linked with bleeding disorders. Studies have indicated that mice deficient in the P2Y12 receptor show decreased tumor metastasis.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Hazard Statements

H412

Precautionary Statements

P273

Hazard Classifications

Aquatic Chronic 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

含少量动物源组分生物产品
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Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders.
Lecchi A
Hamostaseologie (2016)
Thomas H Smith et al.
The Journal of biological chemistry, 292(33), 13867-13878 (2017-06-28)
Vascular inflammation and thrombosis require the concerted actions of several different agonists, many of which act on G protein-coupled receptors (GPCRs). GPCR dimerization is a well-established phenomenon that can alter protomer function. In platelets and other cell types, protease-activated receptor-4
Expression and Localization of Purinergic P2Y12 Receptor in Human Nasal Mucosa
Hideaki Shirasaki
Allergology International (2013)
Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion
Niamh M
BMC Cancer (2015)
Leukotriene E4 induces MUC5AC release from human airway epithelial NCI-H292 cells
Hideaki Shirasaki
Allergology International (2014)
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