Key Documents

View All Documentation

P4871

Anti-Purinergic Receptor P2Y₁₂ antibody produced in rabbit

Name: Anti-Purinergic Receptor P2Y<SUB>12</SUB> antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-ADPG-R, Anti-BDPLT8, Anti-HORK3, Anti-P2T(AC), Anti-P2Y(12)R, Anti-P2Y(AC), Anti-P2Y(ADP), Anti-P2Y(cyc), Anti-P2Y12

Select a Size

Change View

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD04975335

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC, WB

Citations:

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human, mouse, rat

technique(s)

immunohistochemistry: suitable using mouse brain sections, western blot: 1:200 using rat brain membranes or human platelets

UniProt accession no.

Q9H244

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... P2RY12(64805)
mouse ... P2ry12(70839)
rat ... P2ry12(64803)

General description

Purinergic receptor or platelet adenosine 5′-diphosphate (ADP) receptor P2Y12 is a G-protein-coupled receptor. The gene encoding it is localized on human chromosome 3q25.1.

Immunogen

peptide corresponding to amino acid residues 125-142 of human P2Y₁₂. This epitope is highly homologous in rat and mouse (16/18 residues identical).

Application

Anti-Purinergic Receptor P2Y12 antibody produced in rabbit has been used in Western blotting.

Biochem/physiol Actions

Purinergic receptor or platelet adenosine 5′-diphosphate (ADP) receptor P2Y12 has a role in platelet aggregation induced by ADP. Dysfunctional mutations in the protein have been linked with bleeding disorders. Studies have indicated that mice deficient in the P2Y12 receptor show decreased tumor metastasis.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?

Try our Product Selector Tool.

hcodes

H412

pcodes

P273

Hazard Classifications

Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

低风险生物材料

含少量动物源组分生物产品

常规特殊物品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders.

Lecchi A

Hamostaseologie (2016)

Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12-receptor

K. Hoffman

Journal of Thrombosis and Haemostasis (2014)

Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin.

Thomas H Smith et al.

The Journal of biological chemistry, 292(33), 13867-13878 (2017-06-28)

Vascular inflammation and thrombosis require the concerted actions of several different agonists, many of which act on G protein-coupled receptors (GPCRs). GPCR dimerization is a well-established phenomenon that can alter protomer function. In platelets and other cell types, protease-activated receptor-4

Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions.

Bernhard H Rauch et al.

Arteriosclerosis, thrombosis, and vascular biology, 30(12), 2434-2442 (2010-11-13)

The platelet P2Y12 ADP receptor is a well-known target of thienopyridine-type antiplatelet drugs. This study is the first to describe increased transcriptional expression of a functionally active P2Y12 in response to thrombin in human vascular smooth muscle cells (SMC). On

Expression and Localization of Purinergic P2Y12 Receptor in Human Nasal Mucosa

Hideaki Shirasaki

Allergology International (2013)

View All Related Papers

Global Trade Item Number

SKU	GTIN
P4871-200UL	04061837832673

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service