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Merck
CN

P5057

Paromomycin sulfate salt

powder, suitable for cell culture, BioReagent

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About This Item

Empirical Formula (Hill Notation):
C23H45N5O14 · xH2SO4
CAS Number:
1263-89-4
Molecular Weight:
615.63 (free base basis)
UNSPSC Code:
12352207
PubChem Substance ID:
24898585
NACRES:
NA.76
Beilstein/REAXYS Number:
5715182

Key Documents

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Product Name

Paromomycin sulfate salt, powder, BioReagent, suitable for cell culture, potency: ≥675 μg per mg

SMILES string

O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C

InChI

1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

InChI key

OYJABWUHUYVDMJ-UDXJMMFXSA-N

product line

BioReagent

form

powder

potency

≥675 μg per mg

technique(s)

cell culture | mammalian: suitable

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

protein synthesis | interferes

Quality Level

200

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Biochem/physiol Actions

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, some protozoan species, and limited antihelminth.
Mode of Action: Inhibits initiation and elongation during protein synthesis.
Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica, D. fragilis and several cestodes, like Taenia saginata, Taenia solium etc.

Application

  • Paromomycin sulfate salt has been used as a:
  • reference compound in antileishmanial activity
  • RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex.
Recommended for use in cell culture applications at 100mg/L.
Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI).

General description

Chemical structure: aminoglycoside
Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon.

Other Notes

1g,5g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000474741
0000474741
0000424097
0000424097
0000424094

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Paromomycin
Davidson RN, et al.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(7), 653-660 (2009)
Use of a non-adherent cell culture system for testing the effect of 2,3'-dideoxyinosine against Cryptosporidium parvum
Lawton P, et al.
FEMS Microbiology Letters, 176(1), 235-240 (1999)
Leishmaniasis
Manson's Tropical Infectious Diseases (2014)
Antiparasitic Agents
Infectious Diseases, 2, 1345-1372 (2017)
Nanoarchitectures for Neglected Tropical Protozoal Diseases: Challenges and State of the Art
Nano- and Microscale Drug Delivery Systems, 439-480 (2017)
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