P5641
Polyoxyethylene (20) oleyl ether
Synonym(s):
Brij® 98, Brij® 99, C18-1E20
description
non-ionic
InChI
1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-22-20-18-21/h9-10,21H,2-8,11-20H2,1H3/b10-9-
InChI key
KWVPFECTOKLOBL-KTKRTIGZSA-N
General description
Polyoxyethylene (20) oleyl ether is a non-ionic surfactant which can be used as structure-directing agents.
Application
Polyoxyethylene (20) oleyl ether has been used in a study to assess its effect on the transport of ibuprofen across rat skin. It has also been used in a study to investigate novel potential carriers for non-invasive drug delivery.
Legal Information
Brij is a registered trademark of Croda International PLC
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 2 - Skin Irrit. 2
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
>464.0 °F - Equilibrium method
Flash Point(C)
> 240 °C - Equilibrium method
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Synthesis and photocatalytic activity of co-doped mesoporous TiO"2 on Brij98/CTAB composite surfactant template
Zhou, Z., et al.
Journal of Solid State Chemistry, 183, 6-6 (2010)
E S Park et al.
International journal of pharmaceutics, 209(1-2), 109-119 (2000-11-21)
The influence of polyethoxylated non-ionic surfactants on the transport of ibuprofen across rat skin was investigated. The skin permeation of ibuprofen from a series of 17 polyoxyethylene (POE) alkyl ethers containing 5% ibuprofen was determined using Franz diffusion cells fitted
Christian Wachter et al.
Journal of drug targeting, 16(7), 611-625 (2008-08-08)
Novel potential carriers for non-invasive drug delivery were prepared from polyoxyethylene(20) oleyl ether (C(18:1)EO(20)) and soybean phosphatidylcholine (SPC) in different relative molar ratios, R(e); this produced stiff SPC liposomes (2r(ves) approximately 120 nm) at one end and much smaller (2r(mic)
Myriam Chentouf et al.
Journal of immunology (Baltimore, Md. : 1950), 179(1), 409-420 (2007-06-21)
The biological effects of rIgG(1) 13B8.2, directed against the CDR3-like loop on the D1 domain of CD4, are partly due to signals that prevent NF-kappaB nuclear translocation, but the precise mechanisms of action, particularly at the level of membrane proximal
R B Shah et al.
International journal of pharmaceutics, 341(1-2), 189-194 (2007-05-25)
In the present work, a novel application of ultrasonic measurements is detailed to characterize nano-emulsion formulations as a part of the overall Quality by Design (QbD) goal. Ultrasonic resonator technology (URT) was utilized to measure sound velocity and absorption of
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