P5641
Polyoxyethylene (20) oleyl ether
Synonym(s):
Brij® 98, Brij® 99, C18-1E20
InChI
1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-22-20-18-21/h9-10,21H,2-8,11-20H2,1H3/b10-9-
InChI key
KWVPFECTOKLOBL-KTKRTIGZSA-N
description
non-ionic
General description
Polyoxyethylene (20) oleyl ether is a non-ionic surfactant which can be used as structure-directing agents.
Application
Polyoxyethylene (20) oleyl ether has been used in a study to assess its effect on the transport of ibuprofen across rat skin. It has also been used in a study to investigate novel potential carriers for non-invasive drug delivery.
Legal Information
Brij is a registered trademark of Croda International PLC
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Skin Irrit. 2
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
>464.0 °F - Equilibrium method
flash_point_c
> 240 °C - Equilibrium method
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
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Christian Wachter et al.
Journal of drug targeting, 16(7), 611-625 (2008-08-08)
Novel potential carriers for non-invasive drug delivery were prepared from polyoxyethylene(20) oleyl ether (C(18:1)EO(20)) and soybean phosphatidylcholine (SPC) in different relative molar ratios, R(e); this produced stiff SPC liposomes (2r(ves) approximately 120 nm) at one end and much smaller (2r(mic)
E S Park et al.
International journal of pharmaceutics, 209(1-2), 109-119 (2000-11-21)
The influence of polyethoxylated non-ionic surfactants on the transport of ibuprofen across rat skin was investigated. The skin permeation of ibuprofen from a series of 17 polyoxyethylene (POE) alkyl ethers containing 5% ibuprofen was determined using Franz diffusion cells fitted
Synthesis and photocatalytic activity of co-doped mesoporous TiO"2 on Brij98/CTAB composite surfactant template
Zhou, Z., et al.
Journal of Solid State Chemistry, 183, 6-6 (2010)
Yash Kapoor et al.
Journal of colloid and interface science, 322(2), 624-633 (2008-03-25)
Surfactants are commonly incorporated into hydrogels to increase solute loading and attenuate the release rates. In this paper we focus on understanding and modeling the mechanisms of both surfactant and drug transport in hydrogels. Specifically, we focus on Brij 98
Carles Gil et al.
Biochemical and biophysical research communications, 348(4), 1334-1342 (2006-08-22)
Although the high presence of cholesterol in nerve terminals is well documented, specific roles of this lipid in transmitter release have remained elusive. Since cholesterol is a highly enriched component in the membrane microdomains known as lipid rafts, it is
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