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P5669

Sigma-Aldrich

Pyridoxine

≥98%

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Synonym(s):
Pyridoxol, Vitamin B6
Empirical Formula (Hill Notation):
C8H11NO3
CAS Number:
65-23-6
Molecular Weight:
169.18
EC Number:
200-603-0
MDL number:
MFCD00006335
PubChem Substance ID:
24898690

Quality Level

100

Assay

≥98%

form

powder

technique(s)

HPLC: suitable

color

white to off-white

mp

159-162 °C (lit.)

SMILES string

Cc1ncc(CO)c(CO)c1O

InChI

1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3

InChI key

LXNHXLLTXMVWPM-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)

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General description

Pyridoxine (vitamin B6) is a form of vitamin B6. Other forms include the aldehyde pyridoxal and the amide pyridoxamine. It is an important cofactor for metabolism.
Vitamin B group are water-soluble and exists in six forms which includes the pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phospate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. Vitamin B6 is distributed in nuts, whole grains and animal meat.

Application

Pyridoxine has been used as a component of:
  • artificial diet for sugarcane aphid pest
  • modified Strullu and Romand (MSR) medium for carrot root organ culture
  • Luria broth for E coli cultures

Pyridoxine is used in cell culture and other applications as a precursor to pyridoxal phosphate. It has been used as a standard in RP-HPLC (reversed phase high performance liquid chromatography) method. Pyridoxine has been used as a diet supplement to study lipid profile in rats.

Biochem/physiol Actions

Pyridoxine plays a key role in cell maintenance and amino acid metabolism. Deficiency of vitamin B6 leads to anemia especially in pregnant women and seizures in newborns. It serves as cofactor for heme biosynthesis during δ-amino levulinic acid formation, γ-aminobutyric acid (GABA) transaminase and glutamic acid decarboxylase. Vitamin B6 also helps in reactive oxygen species (ROS) scavenging and helps plants in overcoming the abiotic and biotic stress.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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An artificial diet for the sugarcane aphid (Melanaphis sacchari Zehntner)(Hemiptera: Aphididae) with potential uses for in vitro toxicological studies
Toledo-Hernandez E, et al.
Florida entomologist, 101(3), 395-399 (2018)
Henrika Wickström et al.
AAPS PharmSciTech, 18(2), 293-302 (2016-10-16)
Printing technologies were recently introduced to the pharmaceutical field for manufacturing of drug delivery systems. Printing allows on demand manufacturing of flexible pharmaceutical doses in a personalized manner, which is critical for a successful and safe treatment of patient populations with
Design, Validation, and Application of an Enzyme-Coupled Hydrogen Sulfide Detection Assay
Lynch MJ and Crane BR
Biochemistry, 58(6), 474-483 (2018)
Nutrition and anemia in end-stage renal disease
Nutritional Management of Renal Disease, 383-391 (2013)
Seizures caused by pyridoxine (vitamin B6) deficiency in adults: A case report and literature review
Tong Y
Intractable & rare diseases research, 3(2), 52-56 (2014)
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