P5864
Proteoglycan from bovine nasal septum
chromatographically purified
Synonym(s):
Bovine Proteoglycan, Nasal Proteoglycan
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About This Item
Form:
powder
Biological source:
bovine nasal septum
biological source
bovine nasal septum
Quality Level
form
powder
technique(s)
cell culture | stem cell: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
bovine ... PRG4(280867)
General description
Proteoglycans are made up of a core protein to which glycosaminoglycan chains are linked covalently. They are present in many organs, and tissues and found abundantly in the vertebrate cartilage matrix. Proteoglycans are located in the extracellular and pericellular matrix of many cells.
Application
Proteoglycan from bovine nasal septum contains 86% chondroitin sulfate and so has been used to study the effects of chondroitin sulfate proteoglycan in vitro. It has been shown to promote survival of neural stem cells in culture.
Proteoglycan from bovine nasal septum has been used in the induction of arthritis in mice.
Biochem/physiol Actions
Proteoglycans are involved in tissue organization and promote cell growth and specialized tissue maturation. They act as biological filters and regulate collagen fibrillogenesis, skin tensile strength, and neurite growth. Proteoglycans are also involved in modulating growth-factor activities, affecting tumor cell growth and invasion, and promoting corneal transparency.
Preparation Note
Chromatographically purified using 7M urea on DEAE-cellulose by modified procedure by Antonopoulos.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
监管及禁止进口产品
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Articles
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
有五种已发现的糖胺聚糖链（参见图1）透明质酸不是硫酸化的，但其他糖胺聚糖链在链的不同位置含有硫酸根取代基。
Muly Tham et al.
PloS one, 5(12), e15341-e15341 (2010-12-24)
Understanding how autocrine/paracrine factors regulate neural stem cell (NSC) survival and growth is fundamental to the utilization of these cells for therapeutic applications and as cellular models for the brain. In vitro, NSCs can be propagated along with neural progenitors
Antonopoulos, C.A.
Biochimica et Biophysica Acta, 338, 108-119 (1974)
M Kopec et al.
Scientific reports, 9(1), 166-166 (2019-01-19)
We have shown that Raman microspectroscopy is a powerful method for visualization of glycocalyx offering cellular interrogation without staining, unprecedented spatial and spectral resolution, and biochemical information. We showed for the first time that Raman imaging can be used to
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P5864-10MG | 04061834392460 |