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Merck
CN

P6102

Anti-Potassium Channel Kir2.1 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-ATFB9, Anti-HHBIRK1, Anti-HHIRK1, Anti-IRK1, Anti-KIR2.1, Anti-LQT7, Anti-SQT3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02686542
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
western blot (chemiluminescent)
Species reactivity:
rat
Citations:
5
Technique(s):
immunohistochemistry: suitable
western blot (chemiluminescent): 1:200
Uniprot accession no.:
Q64273

Key Documents

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Product Name

Anti-Potassium Channel Kir2.1 antibody produced in rabbit, affinity isolated antibody, lyophilized powder

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

technique(s)

immunohistochemistry: suitable
western blot (chemiluminescent): 1:200

UniProt accession no.

Q64273

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... KCNJ2(3759)
mouse ... Kcnj2(16518)
rat ... Kcnj2(29712)

Biochem/physiol Actions

Potassium voltage-gated channel subfamily J member 2 (KCNJ2) has been shown to have a role in the differentiation and proliferation of bone marrow-derived macrophages (BMDM) in mice. It allows the inward movement of K+ into the cell and maintains its balance. Mutations in the KCNJ2 gene have been linked to Andersen-Tawil syndrome.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Potassium voltage-gated channel subfamily J member 2 (KCNJ2) is an inward-rectifying potassium channel. This tetrameric protein possesses two transmembrane helix domains (M1 and M2), an ion-selective P-loop between M1 and M2 and cytoplasmic amino and carboxy-terminal domains. The gene encoding KCNJ2 is localized on human chromosome 17q24.3.

Immunogen

synthetic peptide corresponding to amino acids 392-410 of human Kir2.1 (with additional N-terminal cysteine). This epitope is identical in rabbit, bovine, pig, and guinea pig and highly homologous in rat, mouse and chicken.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, 1% bovine serum albumin, and 0.025% sodium azide.

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Exclamation mark
GHS07

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Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
含少量动物源组分生物产品
常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
MKCP6453
MKCC7749
MKCC6329
110M1422V
SLBG4011V

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Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3
Ching-Lung C
Nature Genetics (2012)
Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway
Huanxin Liu
Molecular Cancer (2015)
Role of Kir2.1 in human monocyte-derived foam cell maturation
Wei Zhang
Journal of Cellular and Molecular Medicine (2016)
Novel mutation in the KCNJ2 gene is associated with a malignant arrhythmic phenotype of Andersen-Tawil syndrome.
Fernlund E
Annals of Noninvasive Electrocardiology : The Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc (2013)
Association of KCNJ2 Genetic Variants with Susceptibility to Thyrotoxic Periodic Paralysis in Patients with Graves' Disease.
Park S
Experimental and Clinical Endocrinology & Diabetes (2017)

Related Content

Data Sheet - P6102

Instructions

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