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Merck
CN

P6740

Sigma-Aldrich

17-Phenyl-tri-norprostaglandin F2α-ethyl amide

≥95%, solid

Synonym(s):

Bimatoprost

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About This Item

Empirical Formula (Hill Notation):
C25H37NO4
CAS Number:
155206-00-1
Molecular Weight:
415.57
MDL number:
MFCD03411999
UNSPSC Code:
12352211
PubChem Substance ID:
329820253
NACRES:
NA.77

Key Documents

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Quality Level

200

Assay

≥95%

form

solid

storage temp.

−20°C

SMILES string

CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCc2ccccc2

InChI

1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1

InChI key

AQOKCDNYWBIDND-FTOWTWDKSA-N

Gene Information

human ... PTGFR(5737)

Application

Potent FP prostanoid receptor agonist used in animal models for glaucoma.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H302,H360F

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000467313
0000467313
0000467312
0000467312
0000455458

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Wenquan Tang et al.
Medicine, 98(30), e16597-e16597 (2019-07-28)
To evaluated and compared the efficacy and safety of 3 prostaglandin analogues (0.005% latanoprost, 0.004% travoprost, and 0.03% bimatoprost) in treatment of primary open-angle glaucoma (POAG) or ocular hypertension (OHT). PubMed, Embase, Cochrane library, Web of science, CNKI, Wanfang, and
Jocelyn Chua et al.
Molecular vision, 18, 431-438 (2012-02-23)
To determine the proinflammatory cytokine profile of aqueous humor from glaucomatous eyes. Aqueous humor samples were prospectively collected from 38 eyes (26 primary open angle glaucoma [POAG] and 12 primary angle closure glaucoma [PACG] eyes) of 37 medically treated glaucoma
M Abramovitz et al.
Biochimica et biophysica acta, 1483(2), 285-293 (2000-01-15)
Stable cell lines that individually express the eight known human prostanoid receptors (EP(1), EP(2), EP(3), EP(4), DP, FP, IP and TP) have been established using human embryonic kidney (HEK) 293(EBNA) cells. These recombinant cell lines have been employed in radioligand
Chenjia Xu et al.
Journal of ophthalmology, 2020, 2406783-2406783 (2020-08-28)
The aim of this study was to compare the daily costs and cost effectiveness of fixed combination glaucoma drugs in China. This study included the following fixed combination drugs: brinzolamide 1% and timolol 0.5% (Azarga; Alcon, Inc., Fort Worth, TX
Marilita M Moschos et al.
Drug design, development and therapy, 10, 3977-3981 (2016-12-21)
The aim of this study was to investigate the effect of different prostaglandin analogs on platelet-activating factor (PAF) levels. Three prostaglandin analogs were selected: bimatoprost 0.3 mg/mL, latanoprost 50 μg/mL, and tafluprost 15 μg/mL. Each drug sample was tested for
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