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Merck
CN

P6777

Phenelzine sulfate salt

synthetic, ≥98% (iodine, titration), MAO-A/B inhibitor, powder

Synonym(s):

Phenelzine hydrogen sulphate

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About This Item

Empirical Formula (Hill Notation):
C8H12N2 · H2O4S
CAS Number:
156-51-4
Molecular Weight:
234.27
EC Number:
205-856-0
MDL number:
MFCD00050687
UNSPSC Code:
12352200
PubChem Substance ID:
24278646
NACRES:
NA.77

Key Documents

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Product Name

Phenelzine sulfate salt,

biological source

synthetic

Assay

≥98% (iodine, titration)

form

powder

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

SMILES string

NNCCC1=CC=CC=C1.OS(=O)(O)=O

InChI

1S/C8H12N2.H2O4S/c9-10-7-6-8-4-2-1-3-5-8;1-5(2,3)4/h1-5,10H,6-7,9H2;(H2,1,2,3,4)

InChI key

RXBKMJIPNDOHFR-UHFFFAOYSA-N

Gene Information

human ... MAOA(4128), MAOB(4129)

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Related Categories

Biochem/physiol Actions

Non-selective MAO-A/B inhibitor.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK9477
BCCK4308
BCCG9192
BCBN9644V
BCBX0084

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Travis Musgrave et al.
Brain, behavior, and immunity, 25(8), 1677-1688 (2011-07-05)
Multiple sclerosis (MS) and the animal model, experimental autoimmune encephalomyelitis (EAE), are both accompanied by motor and non-motor symptoms. Pathological changes in the activities of key neurotransmitters likely underlie many of these symptoms. We have previously described disturbances in the
Adeline Su-Yin Ngo et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 6(4), 431-434 (2010-07-24)
Phenelzine is an irreversible monoamine oxidase inhibitor (MAOI). Hypertensive reactions after ingestion of tyramine-rich foods such as cheese are well known. However, a review of the available medical literature found no previous reports of myocardial infarction resulting from the ingestion
Marco De Giovanni et al.
Immunity, 56(7), 1548-1560 (2023-06-07)
Cryptococcus neoformans is the leading cause of fungal meningitis and is characterized by pathogenic eosinophil accumulation in the context of type-2 inflammation. The chemoattractant receptor GPR35 is expressed by granulocytes and promotes their migration to the inflammatory mediator 5-hydroxyindoleacetic acid
Marco De Giovanni et al.
Science immunology, 9(93), eadj7363-eadj7363 (2024-03-01)
Peyer's patches (PPs) are lymphoid structures situated adjacent to the intestinal epithelium that support B cell responses that give rise to many intestinal IgA-secreting cells. Induction of isotype switching to IgA in PPs requires interactions between B cells and TGFβ-activating
Ghulam Abbas et al.
Phytotherapy research : PTR, 27(1), 39-45 (2012-03-27)
The current study was aimed at investigating the potential antidepressant activity of Areca catechu nut ethanol extract and its various fractions using behavioral (acute and sub-chronic forced swim tests) and biochemical (monoamines and their metabolite levels using high performance liquid
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Articles

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

血清素合成及代谢

血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。

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