P7265
Prostaglandin A1
≥98% (HPLC), powder, NF-κB inhibitor
Synonym(s):
(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA1
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About This Item
Empirical Formula (Hill Notation):
C20H32O4
CAS Number:
Molecular Weight:
336.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
Beilstein/REAXYS Number:
2003401
Assay:
≥98%
Form:
powder
Product Name
Prostaglandin A1, synthetic
biological source
synthetic
Quality Segment
assay
≥98%
form
powder
storage temp.
−20°C
SMILES string
O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)C=C1
InChI
1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1
InChI key
BGKHCLZFGPIKKU-LDDQNKHRSA-N
Biochem/physiol Actions
Prostaglandin A1 (PGA1) is a cyclopentenone prostaglandin containing chemically reactive α,β-unsaturated carbonyl. This cyclooxygenase 2 (COX-2) metabolic product aids in regulating the development and progression of Alzheimer′s disease (AD). In addition, PGA1 also regulates various biological processes via Michael addition. It exhibits antiviral activity against avian influenza A viruses (IAV) by inducing cytoprotective heat shock response in infected cells and by inhibiting nuclear factor-κB (NF-κB) activity.
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Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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