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P7443

L-α-Phosphatidylcholine

Name: <SC>L</SC>-α-Phosphatidylcholine
Brand: SIGMA

from soybean, ≥99% (TLC), lyophilized powder

Synonym(s):

1,2-Diacyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, L-α-Lecithin, Azolectin, PC

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About This Item

CAS Number:

8002-43-5

UNSPSC Code:

12352211

NACRES:

NA.25

EC Number:

232-307-2

Beilstein/REAXYS Number:

5209585

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biological source

soybean

Quality Level

200

assay

≥99% (TLC)

form

lyophilized powder

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

SMILES string

[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCCCCCCCCCC)OCC[N+](C)(C)C

InChI

1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1

InChI key

JLPULHDHAOZNQI-ZTIMHPMXSA-N

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Biochemicals

General description

L-α-Phosphatidylcholine (PC) is an asymmetric molecule with glycerol backbone and occurs naturally in lecithin of egg yolk. It is a phospholipid and major choline source in mammalian cells. It is crucial for very low-density lipoprotein secretion in hepatocytes. It is essential for the acetylcholine synthesis functions to nourish the brain. PC plays a crucial role in lipid and lipoprotein metabolism. Deficiencies of enzymes in PC biosynthetic pathway leads to an array of metabolic disorder. Intracellular levels of hepatic PC to phosphatidylethanolamine (PE) ratio contributes to pathophysiology non-alcoholic fatty liver disease (NAFLD). It has anti-inflammatory functionality and is effective in treating inflammatory bowel disease. PC administration therapy is effective for treating benign symmetric lipomatosis.

Application

L-α-Phosphatidylcholine has been used:

for liposome preparation
as a component of stabilizer solution for preparing dispersed curcuminoid submicron particle (CSP)
as a component of serum free substitute for whole blood cells

Biochem/physiol Actions

A major structural phospholipid in brain, comprising approx. 15% of total lipid; primarily localized to gray matter.

Packaging

Packaged under Argon

Preparation Note

Prepared by a modification of the procedure of Singleton, W.S., et al., J. Am. Oil Chem. Soc., 42, 53 (1965).

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000479521

0000466947

0000448765

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A pollen protein, NaPCCP, that binds pistil arabinogalactan proteins also binds phosphatidylinositol 3-phosphate and associates with the pollen tube endomembrane system.

Christopher B Lee et al.

Plant physiology, 149(2), 791-802 (2008-12-23)

As pollen tubes grow toward the ovary, they are in constant contact with the pistil extracellular matrix (ECM). ECM components are taken up during growth, and some pistil molecules exert their effect inside the pollen tube. For instance, the Nicotiana

Curcuminoid submicron particle ameliorates cognitive deficits and decreases amyloid pathology in Alzheimer?s disease mouse model

Tai YH, et al.

Oncotarget, 9(12), 10681-10681 (2018)

PERIPHERAL BLOOD PROGENITOR CELLS-Storage of unprocessed G-CSF-mobilized whole blood in a modified Leibovitz's L15 medium preserves clonogenic capacity for at least 7 days

Kreuk AM de, et al.

Bone Marrow Transplantation, 28(2), 145-156 (2001)

The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease

van der Veen JN, et al.

Biochimica et Biophysica Acta - Biomembranes, 1859(9), 1558-1572 (2017)

Lipid based therapy for ulcerative colitis?modulation of intestinal mucus membrane phospholipids as a tool to influence inflammation

Schneider H, et al.

International Journal of Molecular Sciences, 11(10), 4149-4164 (2010)

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Global Trade Item Number

SKU	GTIN
P7443-1G	04061834395225
P7443-100MG	04061834395195
P7443-500MG	04061834395232

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